An imbalance of COX level is not related to placental abruption

Avagliano, Laura; Falleni, Monica; Marconi, Anna Maria; Bulfoni, Camilla; Prada, A.; Barbera, Antonio; Doi, Patrizia; Bulfamante, Gaetano

doi:10.1136/jcp.2010.088765

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…A link between inflammation and bleeding was reported by many researchers [ 21 , 40 , 47 , 48 , 53 ]. Moreover, according to Mhatre et al (2016) [ 21 ], a similar inflammatory response may be driven both by lipopolysaccharide (LPS) and THR, achieving a multiplied effect when acting together (see Table 3 ).…”

Section: Resultsmentioning

confidence: 95%

“…As a result of the described procedure, 22 articles that met all the inclusion criteria were retrieved [ 20 , 21 , 27 , 29 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Extracted data included in this systematic review are collected in Table S2 .…”

Section: Resultsmentioning

confidence: 99%

“…The role of cyclooxygenases (COXs) at the time of implantation and during pregnancy is well known, with successful implantation being associated with the prostaglandin (PGs) induction by COX1 and COX2 [ 88 , 89 ]. A precise balance between COX-negative and COX-positive cells is necessary to ensure the adequate production of PGs and to allow a physiological evolution of pregnancy [ 48 ]. Placental COX1 and COX2 activities were reported to be decreased in case of PE [ 90 , 91 ], while fetal COX2 polymorphism was suspected to contribute to the development of FGR [ 92 ].…”

Section: Resultsmentioning

confidence: 99%

“…The role of COXs in placental abruption remains unclear and the research is still ongoing. Following Avagliano et al (2011) [ 48 ], the imbalance of COXs seems to be unassociated with the pathogenesis of placental abruption, while Singh et al (2019) found an increased expression of COX2 in the amnion in placental abruption [ 53 ]. Furthermore, Nishimura et al (2020) found an increased expression of COX2 in the myometrium treated with THR [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

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Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Bączkowska

Zgliczyńska

Faryna³

et al. 2021

IJMS

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Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear. The aim of this review was to examine the current state of knowledge concerning the molecular changes on the maternal–fetal interface occurring in placental abruption. Only original research articles describing studies published in English until the 15 March 2021 were considered eligible. Reviews, book chapters, case studies, conference papers and opinions were excluded. The systematic literature search of PubMed/MEDLINE and Scopus databases identified 708 articles, 22 of which were analyzed. The available evidence indicates that the disruption of the immunological processes on the maternal–fetal interface plays a crucial role in the pathophysiology of placental abruption. The features of chronic non-infectious inflammation and augmented immunological cytotoxic response were found to be present in placental abruption samples in the reviewed studies. Various molecules participate in this process, with only a few being examined. More advanced research is needed to fully explain this complicated process.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Bączkowska

Zgliczyńska

Faryna³

et al. 2021

IJMS

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“…Ptgs2 is important in the endocannabinoid system and there is now evidence to show that factors (PGE2, Ptgs2, etc.) involved in this pathway in placenta may have a role in ovulation, implantation, and decidualization [ 22 , 23 ] and abnormal expression may result in spontaneous miscarriage, placental abruptions, and poor pregnancy outcomes [ 24 , 25 ]. Prostaglandins increase myometrial sensitivity and PTGS2 is especially associated with changing myometrial contractility during pregnancy [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta

Vaswani

Chan

Peiris

et al. 2015

Mediators of Inflammation

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Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated in the placenta and decidual tissues throughout pregnancy and aberrant endocannabinoid signaling during the period of placental development has been associated with pregnancy disorders. In this study, the gene expression of eight endocannabinoid system enzymes was investigated throughout gestation. Rat placentae were obtained at E14.25, E15.25, E17.25, and E20, RNA was extracted, and microarray was performed. Gene expression of enzymes Faah, Mgll, Plcd4, Pld1, Nat1, Daglα, and Ptgs2 was studied (cohort 1, microarray). Biological replication of the results was performed by qPCR (cohort 2). Four genes showed differential expression (Mgll, Plcd4, Ptgs2, and Pld1), from mid to late gestation. Genes positively associated with gestational age were Ptgs2, Mgll, and Pld1, while Plcd4 was downregulated. This is the first comprehensive study that has investigated endocannabinoid pathway gene expression during rat pregnancy. This study provides the framework for future studies that investigate the role of endocannabinoid system during pregnancy.

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Immunological mechanisms of preterm abruption of the normally located placenta

Lazareva,

Fatkullina

2024

V.F.Snegirev Archives of Obstetrics and Gynecology

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Data from the modern scientific literature concerning the etiology and pathogenesis of preterm abruption of normally located placenta were analyzed. Preterm placental abruption is a rare but very dangerous condition for the mother and fetus. This clinical situation occurs very quickly, and its consequences can be fatal. Because placental abruption can cause disability of the mother and fetus, it should be classified as a social problem. This review included data from international and Russian articles published over the past decade. This literature review aimed to examine modern theories about molecular changes in the fetoplacental complex that occur during placental abruption. Available evidence suggests that disruption of immunological processes at the maternal–fetal interface is of key significance in the pathophysiology of placental abruption. The reviewed studies described signs of chronic noninfectious inflammation and an enhanced immunological cytotoxic response in placental abruption. Currently, obstetrics is a risk-based approach to medical care for pregnant women. Thus, understanding the predictors and mechanisms of the formation of this pregnancy complication is the key to predicting complications and providing highly competent medical care to patients.

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An imbalance of COX level is not related to placental abruption

Abstract: It is hypothesised that an imbalance of normal COX level may be present in cases with MA and CA but it is not related to placental abruption.

Cited by 5 publications

References 33 publications

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review

Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta

Immunological mechanisms of preterm abruption of the normally located placenta

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