Abstract:Psychological constructs, such as negative affect and substance use cravings that closely predict relapse, show substantial intra-individual day-to-day variability. This intra-individual variability of relevant psychological states combined with the “one day of a time” nature of sustained abstinence warrant a day-to-day investigation of substance use recovery. This study examines day-to-day associations among substance use cravings, negative affect, and tobacco use among 30 college students in 12-step recovery… Show more
“…Table 2 presents fit statistics for (1) wholesample-aggregated estimates versus (2) treatmentspecific parameters (the latter better fit observed data). A third, exploratory, model (3) tested the fit of subgroups of participants based on the technique of Zheng et al for K-cluster analysis of their model parameters [13]. Four ORIGINAL RESEARCH clusters emerged, summarized in the first, seventh, and eighth columns of Table 1.…”
Section: Resultsmentioning
confidence: 99%
“…As with RCTs, ICTs might identify subgroups of clients/patients but do so by identifying similarities among the individuals (e.g., homogeneous clusters) in terms of trends of outcomes or related characteristics, in a bottom-up manner [13]. Population inferences are usually not the purpose of an ICT.…”
Section: Discussionmentioning
confidence: 99%
“…Unified structural equation modeling (USEM) is a form of state-space modeling which in some ways resembles SEM but models observation-toobservation changes (e.g., day-to-day or session-to-session) within individuals [13]. Chow et al [11] review consistencies and differences between USEM and SEM including their relative strengths and weaknesses with regard to investigating intraindividual change and interindividual variability.…”
Section: Analytic Techniquesmentioning
confidence: 99%
“…For example, the fit statistics used herein for state-space model testing have established literatures and examples in the literature within time series data and ICT contexts [11,13]. Yet, alternative statistics may be more appropriate, offer greater power (in the case of LR χ 2 ), or provide requisite conservative adjustments of which the field is not yet aware.…”
Section: Analytic Techniquesmentioning
confidence: 99%
“…Cross-lag model mediations between relationship satisfaction and depression were analyzed within individuals (see Fig. 2, later) [13,22]. Herein, MMTA was conducted twice: first for outcomes as treatment was administered and again with 12-month outcomes added to explore differences between their results [23].…”
A critical juncture in translation research involves the preliminary studies of intervention tools, provider training programs, policies, and other mechanisms used to leverage knowledge garnered at one translation stage into another stage. Potentially useful for such studies are rigorous techniques for conducting within-subject clinical trials, which have advanced incrementally over the last decade. However, these methods have largely not been utilized within prevention or translation contexts. The purpose of this manuscript is to demonstrate the flexibility, wide applicability, and rigor of idiographic clinical trials for preliminary testing of intervention mechanisms. Specifically demonstrated are novel uses of state-space modeling for testing intervention mechanisms of short-term outcomes, identifying heterogeneity in and moderation of within-person treatment mechanisms, a horizontal line plot to refine sampling design during the course of a clinic-based experimental study, and the need to test a treatment's efficacy as treatment is administered along with (e.g., traditional 12-month outcomes).
“…Table 2 presents fit statistics for (1) wholesample-aggregated estimates versus (2) treatmentspecific parameters (the latter better fit observed data). A third, exploratory, model (3) tested the fit of subgroups of participants based on the technique of Zheng et al for K-cluster analysis of their model parameters [13]. Four ORIGINAL RESEARCH clusters emerged, summarized in the first, seventh, and eighth columns of Table 1.…”
Section: Resultsmentioning
confidence: 99%
“…As with RCTs, ICTs might identify subgroups of clients/patients but do so by identifying similarities among the individuals (e.g., homogeneous clusters) in terms of trends of outcomes or related characteristics, in a bottom-up manner [13]. Population inferences are usually not the purpose of an ICT.…”
Section: Discussionmentioning
confidence: 99%
“…Unified structural equation modeling (USEM) is a form of state-space modeling which in some ways resembles SEM but models observation-toobservation changes (e.g., day-to-day or session-to-session) within individuals [13]. Chow et al [11] review consistencies and differences between USEM and SEM including their relative strengths and weaknesses with regard to investigating intraindividual change and interindividual variability.…”
Section: Analytic Techniquesmentioning
confidence: 99%
“…For example, the fit statistics used herein for state-space model testing have established literatures and examples in the literature within time series data and ICT contexts [11,13]. Yet, alternative statistics may be more appropriate, offer greater power (in the case of LR χ 2 ), or provide requisite conservative adjustments of which the field is not yet aware.…”
Section: Analytic Techniquesmentioning
confidence: 99%
“…Cross-lag model mediations between relationship satisfaction and depression were analyzed within individuals (see Fig. 2, later) [13,22]. Herein, MMTA was conducted twice: first for outcomes as treatment was administered and again with 12-month outcomes added to explore differences between their results [23].…”
A critical juncture in translation research involves the preliminary studies of intervention tools, provider training programs, policies, and other mechanisms used to leverage knowledge garnered at one translation stage into another stage. Potentially useful for such studies are rigorous techniques for conducting within-subject clinical trials, which have advanced incrementally over the last decade. However, these methods have largely not been utilized within prevention or translation contexts. The purpose of this manuscript is to demonstrate the flexibility, wide applicability, and rigor of idiographic clinical trials for preliminary testing of intervention mechanisms. Specifically demonstrated are novel uses of state-space modeling for testing intervention mechanisms of short-term outcomes, identifying heterogeneity in and moderation of within-person treatment mechanisms, a horizontal line plot to refine sampling design during the course of a clinic-based experimental study, and the need to test a treatment's efficacy as treatment is administered along with (e.g., traditional 12-month outcomes).
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