An identical mechanism governs self-nonself discrimination and effector class regulation

Abstract

Prevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen.Representing a cardinal departure from the past, our model instead predicts both selfnonself discrimination and effector class regulation are in fact one and the same process AbstractPrevailing immunological dogma dictates self-nonself discrimination, meaning to respond or not, and effector class regulation, meaning choosing the most effective response, are two separate decisions the immune system makes when faced with a new antigen. Representing a cardinal departure from the past, our model instead predicts both self-nonself discrimination and effector class regulation are in fact one and the same process controlled by Foxp3 + regulatory T cells (Tregs) whose antigen-specific repertoire is entirely maintained by commensal microbiotaderived cross-reactive antigens.

Stressor-Dependant Changes in Immune Parameters in the Terrestrial Isopod Crustacean, Porcellio scaber: A Focus on Nanomaterials

“…The role of the immune system is to distinguish between the self and non-self and to choose the most effective response to exogenous or endogenous threats, in order to maintain the integrity and homeostasis of the organism [ 1 , 2 , 3 ]. The immune recognition and response mechanisms of crustaceans depend entirely on the innate immune system.…”