An ICT-switched fluorescent probe for visualizing lipid and HClO in lipid droplets during ferroptosis

Abstract

An ICT-switched fluorescent probe has been developed for the visualization of the lipid accumulation and hypochlorous acid in lipid droplets during ferroptosis.

Unraveling Ferroptosis Mechanisms: Tracking Cellular Viscosity with Small Molecular Fluorescent Probes

“…One such method could be tracking the microenvironment associated with cells, such as pH, polarity, and viscosity. [20][21][22][23] Also, elevated level various ROS such as hydrogen peroxide (H 2 O 2 ), [24] hydroxyl radical ( * OH), [25] superoxide anion radical (O 2 *À ), [26] and hypochloric acid/hypochlorite (HClO/ClO À ), [27][28][29] etc., reactive nitrogen species (RNS) such as peroxynitrite (ONOO À ), [20,30] and reduced level of various reactive sulfur species (RSS) [31][32][33] such as cysteine, glutathione, etc., during ferroptosis can be an indirect tool for monitoring ferroptosis.…”

A triphenylamine-based fluorescent probe with large Stokes shift for wash-free imaging of lipid droplets and diagnosis of fatty liver

“…10–12 Dysregulation of their functions may contribute to liver steatosis, type II diabetes, and atherosclerosis. 13–17 Therefore, a breakthrough in the investigation of monitoring abnormal changes in LDs will assume an indispensable role in future disease prevention and therapeutic surveillance.…”

A Hypochlorite-Activated Theranostic Prodrug for Selective Imaging of High Myeloperoxidase Expression Acute Myeloid Leukemia Cells and Drug Release

“…In recent years, some HClO-responsive fluorescent probes − and theranostic agents , have been developed. Fluorescence imaging has the advantages of perceptual intuition, real-time analysis, low cost, and lack of radiation. − As the overproduction of HClO is involved in many diseases such as cancer and inflammation, new probes that can selectively detect HClO/ClO – in AML cells are required.…”