An ICT-based fluorescent probe guided by theoretical calculation for selectively mapping endogenous GSH in living cells

Chen, Jiao; Li, Yiwei; Feng, Xukai; She, Mengyao; Yao, Wenxin; Leng, Xiaojing; Liu, Ping; Zhang, Shengyong; Li, Jianli

doi:10.1016/j.saa.2020.119041

Cited by 14 publications

(2 citation statements)

References 42 publications

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“…Second, the photoluminescence properties, especially high QY, should be reckoned 154 - 163 . Based on the photochemical mechanisms such as PET 164 - 167 , FRET 168 - 170 , ICT 171 - 173 , fluorescent probes with long emission wavelengths will be developed continuously. Additionally, the QY and photochemical stability are critical for the usefulness of the fluorescent probes.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Activatable NIR-II organic fluorescent probes for bioimaging

Zhang¹,

Li²,

Ma³

et al. 2022

Theranostics

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NIR-II imaging is developed rapidly for noninvasive deep tissue inspection with high spatio-temporal resolution, taking advantage of diminished autofluorescence and light attenuation. Activatable NIR‐II fluorescence probes are widely developed to report pathological changes with accurate targeting, among which organic fluorescent probes achieve significant progress. Furthermore, the activatable NIR‐II fluorescent probes exhibited appealing characteristics like tunable physicochemical and optical properties, easy processability, and excellent biocompatibility. In the present review, we highlight the advances of activatable NIR-II fluorescence probes in design, synthesis and applications for imaging pathological changes like reactive oxygen species (ROS), reactive nitrogen species (RNS), reactive sulfur species (RSS), pH, hypoxia, viscosity as well as abnormally expressed enzymes. This non-invasive optical imaging modality shows a promising prospect in targeting the pathological site and is envisioned for potential clinical translation.

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Section: Conclusion and Perspectivementioning

confidence: 99%

Activatable NIR-II organic fluorescent probes for bioimaging

Zhang¹,

Li²,

Ma³

et al. 2022

Theranostics

View full text Add to dashboard Cite

show abstract

“…[35][36][37][38] From the perspective of molecular design, the reaction between the probe and biothiols should be reversible. Among the extensively studied reaction mechanisms for biothiol detection, such as nucleophilic substitution, [39][40][41] nucleophilic addition and cyclization, [42][43][44] Michael addition, [36][37][38] and multisite reaction strategy, [45][46][47] Michael addition is more reasonable to build a reversible probe credited to its nature of reversibility. Wang and coworkers reported the rst uorescent probe ThiolQuant Green (TQ Green) for quantitative detection of GSH in living cells through carefully adjusting the properties of the Michael acceptor.…”

Section: Introductionmentioning

confidence: 99%