“…It was not until the 1960s that the concept of “secondary amyloidosis” in patients with chronic inflammatory conditions was introduced and ultimately sequenced as AA protein. 5 Since then, determining an accurate prevalence of AA amyloidosis has been difficult, as a tissue diagnosis is not always performed and the management of chronic inflammatory conditions such as rheumatoid arthritis and inflammatory bowel disease have evolved. Estimates in European studies describe an incidence of AA amyloidosis of 1 to 2 patients per million life-years.…”