An heuristic-based selection process for organic solvent nanofiltration membranes

Blumenschein, Stefanie; Kätzel, Uwe

doi:10.1016/j.seppur.2017.03.001

Cited by 14 publications

(2 citation statements)

References 32 publications

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“…Theoretically, the osmotic pressures of 2 M LiCl in both solvents should be identical according to the original van't Hoff’s equation π = icRT 33 , 34 . However, LiCl may undergo a higher degree of dissociation and generate more ion species in ethanol than in IPA due to the higher polarity of ethanol 36 . This hypothesis is confirmed because 2 M LiCl in ethanol has a much higher conductivity (6.78 ± 0.03 ms cm −1 ) than that in IPA (1.18 ± 0.01 ms cm −1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, based on their Hansen solubility parameters calculated from the group contribution method, the solubility parameter difference between tetracycline and the membrane is relatively large (i.e., 28.7 vs. 23 MPa 1/2 ) 43 , 44 . Therefore, they have a low affinity towards each other and the tetracycline solubility in the membrane might be small 36 , 45 . The combination of low diffusivity and solubility leads to a relatively low tetracycline flux of 0.098 LMH (as revealed in Supplementary Table 3 and the determination method can be found in Supplementary Methods ) and thus, a high membrane rejection of tetracycline.…”

Section: Resultsmentioning

confidence: 99%

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Pharmaceutical concentration using organic solvent forward osmosis for solvent recovery

2018

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The organic solvent forward osmosis (OSFO) process can simultaneously concentrate the active pharmaceutical ingredients (APIs) and recover the organic solvents. Here we demonstrate and evaluate an OSFO process for solvent recovery. In this demonstration, OSFO was conducted in different solvents with different draw solutes. The OSFO process shows rejections >98% when recovering organic solvents from different feed solutions, even when the feed concentration is as high as 20 wt%. More importantly, all systems exhibit relatively low ratios of reverse solute flux to solvent flux, indicating that the adverse effects of using hazardous draw solutions could be minimized. Nevertheless, the use of non-hazardous draw solutes such as citric acid is highly recommended to remove any potential risk, and it has been demonstrated. Herein, the OSFO process is a promising technology for solvent recovery as it possesses a reasonable solvent flux, low reverse solute flux and requires no external pressure.

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Section: Resultsmentioning

confidence: 99%