An fMRI study of neuronal specificity of an acupoint: Electroacupuncture stimulation of Yanglingquan (GB34) and its sham point

Na, Byung-Jo; Jahng, Geon‐Ho; Park, Seong-uk; Jung, Woo-Sang; Moon, Sang-Kwan; Park, Jung‐Mi; Bae, Hyung-sup

doi:10.1016/j.neulet.2009.08.009

Cited by 57 publications

(40 citation statements)

References 19 publications

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“…The function [59], whereas very few areas were activated when SHAM was given [60]. Through these results, we confirmed that our experimental methods were clear and resulted in our acceptance of the results.…”

Section: Discussionsupporting

confidence: 79%

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Kim¹,

Song²,

Kim³

et al. 2017

J Int Korean Med

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Background: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease (PD). Methods: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field.Results: Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere. Conclusions:The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson's disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson's disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy.Trial registration: KCT0001122 at cris.nih.go.kr (registration date: 20140530)

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Section: Discussionsupporting

confidence: 79%

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Kim¹,

Song²,

Kim³

et al. 2017

J Int Korean Med

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“…Thus, differences between the results of the current study and prior studies reporting limbic and default mode network (DMN) deactivations (e.g., Hui et al) 18 may have been caused by the current authors' more-conservative threshold with cluster-correction for multiple comparisons, although other differences also included the use of electrical versus manual stimulation and event versus block protocol designs. Previous EA fMRI studies showed that EA at GB 34 produced deactivation in only a rostral segment of the anterior cingulate cortex (ACC), 19 or none at all, 20 while broad brain activation was noted in multiple areas-such as the postcentral gyrus, insula, thalamus, and prefrontal cortex-in both studies.…”

Section: Discussionmentioning

confidence: 72%

Acupuncture Evoked Response in Contralateral Somatosensory Cortex Reflects Peripheral Nerve Pathology of Carpal Tunnel Syndrome

Maeda

Kettner

Lee

et al. 2013

Medical Acupuncture

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Background: Most neuroimaging studies exploring brain response to different acupoints have been performed in healthy adults. Objective: The aim of this study was to compare brain responses to acupuncture at local versus distal acupoints in patients with carpal tunnel syndrome (CTS), who have chronic pain, versus healthy controls (HC) and correlate these responses with median nerve function. Materials and Methods: Brain response to electroacupuncture (EA; 2Hz) was evaluated with event-related functional MRI (fMRI) in patients with CTS (n = 37) and age-matched HC (n = 30). EA was applied at acupoints local (PC 7 to TW 5) and distal (SP 6 to LV 4) to the CTS lesions. Results: Brain response in both groups and acupoints included activation of the bilateral secondary somatosensory cortex (S2) and insula, and the contralesional primary somatosensory cortex (cS1). Deactivation was noted in ipsilesional primary somatosensory cortex (S1). A significant difference between local and distal acupoints was found in cS1 for HC, but not CTS. Furthermore, cS1 activation by EA at local acupoints was negatively correlated with median nerve peak sensory latency in HC, but was positively correlated in CTS. No correlation was found for EA at distal acupoints for either group. Conclusions: Brain response to EA differs between CTS and HC and, for local acupoint stimulation, is associated with median nerve function, reflecting the peripheral nerve pathophysiology of CTS.

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“…Recently, many PD model studies suggest that stimulation at acupoint GB34 and ST36 could enhance motor function and promote dopaminergic cells against toxic insults [31][32][33][34]. Studies of fMRI on human subjects found that stimulation on GB34 activated motor-related brain regions such as the putamen, caudate nucleus and thalamus and cerebellum [66]. The efficacy of other acupoints used in the studies was barely investigated.…”

Section: Discussionmentioning

confidence: 99%

Effect of Acupuncture on the Motor and Nonmotor Symptoms in Parkinson's Disease—A Review of Clinical Studies

Zeng

Zhao

2016

CNS Neurosci Ther

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Parkinson's disease is a neurodegenerative disorder. Parkinson's clinical feature is characterized by its motor manifestations, although its many nonmotor symptoms occur earlier and have more profound impact on the quality of patient's life. Acupuncture has been increasingly popular and has been used to treat patients with Parkinson's. In this article, we have studied the clinical reports of acupuncture treatment for Parkinson's, which were listed in Medline, PubMed, EMBASE, CNKI, and CINAHL databases in the past 15 years. It was found that acupuncture either manual or electroacupuncture stimulation at specific acupoints relieved some motor symptoms in patients with Parkinson's and markedly improved many nonmotor symptoms such as psychiatric disorders, sleep problems, and gastrointestinal symptoms. When it was used as an adjunct for levodopa, acupuncture improved therapeutic efficacy and reduced dosage and the occurrence of side effects of levodopa. However, the results were constrained by small sample sizes, methodological flaws, and blinding methods of studies. Although the evidence for the effectiveness of acupuncture for treating Parkinson's is inconclusive, therapeutic potential of acupuncture seems quite promising. More studies, either comparative effectiveness research or high-quality placebo-controlled clinical studies are warranted.

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An fMRI study of neuronal specificity of an acupoint: Electroacupuncture stimulation of Yanglingquan (GB34) and its sham point

Cited by 57 publications

References 19 publications

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

A Case Report of Drug-Induced Parkinsonism Treated with Jodeung-san and Electro-acupuncture at GB34

Acupuncture Evoked Response in Contralateral Somatosensory Cortex Reflects Peripheral Nerve Pathology of Carpal Tunnel Syndrome

Effect of Acupuncture on the Motor and Nonmotor Symptoms in Parkinson's Disease—A Review of Clinical Studies

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