An fMRI investigation of covertly and overtly produced mono- and multisyllabic words

Shuster, Linda; Lemieux, Susan K.

doi:10.1016/j.bandl.2004.07.007

Cited by 176 publications

(142 citation statements)

References 50 publications

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“…Thus, the computational load of the planning process should vary with the number of syllable-sized motor programs that need to be retrieved and assembled. On the assumption that multisyllable words require more syllable-sized motor routines than monosyllable words, Shuster and Lemieux (2005) used word length to vary the computational load of planning. It should be noted, however, that their study did not control for utterance length and syllable frequency.…”

Section: Introductionmentioning

confidence: 99%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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a b s t r a c t a r t i c l e i n f oUsing an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable, multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to nonstuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about stuttering and to clinical applications.

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Section: Introductionmentioning

confidence: 99%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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“…One strategy for studying narrative production involves examining activation during inner speech (Wildgruber, Ackermann, Klose, Kardatzki, & Grodd, 1996;Wildgruber, Ackermann, & Grodd, 2001). The results of studies involving inner speech are often compatible with those involving actual speech production (Palmer et al, 2001;Rosen, Ojemann, Ollinger, & Petersen, 2000;Shuster & Lemieux, 2005), although this work has focused on single words. Moreover, we wanted to ensure that we were monitoring brain activity during coherent, full narrative production where discourse organization must be explicit rather than during a kind of mental shorthand where organizational links crucial to the coherence of a narrative may not be fully realized.…”

Section: Introductionmentioning

confidence: 99%

“…Additional reports describe studies of speech production during fMRI (Palmer et al, 2001;Rosen et al, 2000;Shuster et al, 2005). fMRI has many advantages over PET due to its superior spatial resolution, non-invasiveness, and absence of ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

Narrative speech production: An fMRI study using continuous arterial spin labeling

et al. 2008

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Functional magnetic resonance imaging (fMRI) with continuous arterial spin labeling (CASL) was employed to monitor brain activation during narrative production of a semi-structured speech sample in healthy young adults. Subjects were asked to describe a wordless children's picture story. Significant activations were found in bilateral prefrontal and left temporal-parietal regions during narrative production relative to description of a single picture and relative to viewing the wordless picture story while producing a nonsense word. We conclude that an inferior frontal cortex serves as a top-down organizational resource for narrative comprehension and demonstrate the feasibility of collecting extended speech samples using CASL perfusion fMRI.

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“…1). The first ROI expected to activate during articulation was the middle portion of the primary sensorimotor cortex (Paus et al, 1996;Indefrey and Levelt, 2000;Lotze et al, 2000;Riecker et al, 2000;Shuster and Lemieux, 2005;Riecker et al, 2005). This ROI included the right and left pre-and postcentral gyri, extending from z = 20 mm to 60 mm.…”

Section: Resultsmentioning

confidence: 99%

“…There is much interest in conducting fMRI studies to examine the neurological control for the articulation of speech (Lotze et al, 2000;Riecker et al, 2000;Shuster and Lemieux, 2005;Riecker et al, 2005). Thus far, these experiments have relied on event-related designs and/or subject averaging to reduce the presence of false activation caused by task-correlated orofacial motion.…”

Section: Introductionmentioning

confidence: 99%

High spatial resolution increases the specificity of block-design BOLD fMRI studies of overt vowel production

Soltysik

Hyde

2008

NeuroImage

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Functional MRI (fMRI) studies of tasks involving orofacial motion, such as speech, are prone to problems related to motion-induced magnetic field variations. Orofacial motion perturbs the static magnetic field, leading to signal changes that correlate with the task and corrupt activation maps with false positives or signal loss. These motion-induced signal changes represent a contraindication for the implementation of fMRI to study the neurophysiology of orofacial motion. An fMRI experiment of a structured, non-semantic vowel production task was performed using four different voxel volumes and three different slice orientations in an attempt to find a set of acquisition parameters leading to activation maps with maximum specificity. Results indicate that the use of small voxel volumes (2×2×3 mm 3 ) yielded a significantly higher percentage of true positive activation compared to the use of larger voxel volumes. Slice orientation did not have as great an impact as spatial resolution, although coronal slices appeared superior at high spatial resolutions. Furthermore, it was found that combining the strategy of high spatial resolution with an optimum task duration and postprocessing methods for separating true and false positives greatly improved the specificity of singlesubject, block-design fMRI studies of structured, overt vowel production.

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An fMRI investigation of covertly and overtly produced mono- and multisyllabic words

Cited by 176 publications

References 50 publications

The neural substrates for atypical planning and execution of word production in stuttering

The neural substrates for atypical planning and execution of word production in stuttering

Narrative speech production: An fMRI study using continuous arterial spin labeling

High spatial resolution increases the specificity of block-design BOLD fMRI studies of overt vowel production

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