An Extremely Rare Nasopharyngeal Malignant Tumor: A Case Report

Karamitsou, Paraskevi; Poutoglidis, Alexandros; Skliris, James Philip; Matzarakis, Ioannis; Gougousis, Spyridon

doi:10.7759/cureus.31444

Cited by 3 publications

(2 citation statements)

References 19 publications

(40 reference statements)

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“…The nasal cavity may host a variety of rare neoplasms [ 15 ]. Misdiagnosis of neurofibromas is not uncommon.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of a Large Sinonasal Neurofibroma

Skalias¹,

Karamitsou²,

Poutoglidis³

et al. 2022

Cureus

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A neurofibroma is a benign peripheral nerve sheath tumor. Its appearance in the nose and paranasal sinuses is extremely rare. We present the case of a 61-year-old female with a large sinonasal neurofibroma. The patient was referred to our department due to the findings of a large invasive lesion originating from the left sinus with extension to the adjacent structures on computed tomography. A thorough examination revealed a mass within the left nasal cavity and exophthalmos. The initial symptoms of the disease probably appeared three years ago when she reported that she developed facial swelling following dental work. In the following period and due to reported blurred vision, she consulted with several medical specialists without receiving a diagnosis, while later she visited an otorhinolaryngologist, complaining of ear fullness, and local treatment was prescribed. Due to persistent symptoms, the patient was finally referred for computed tomography. Upon arrival at our department, she underwent a biopsy, which revealed the existence of a neurofibroma. The patient underwent endoscopic resection of the tumor and remains under close follow-up with no signs of recurrence. Sinonasal neurofibroma is a rare condition that presents with non-specific symptoms and may take years to reach a diagnosis. Open or endoscopic surgical resection seems to offer satisfactory results; however, similar cases reported in the literature are scarce.

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“…The nasal cavity may host a variety of rare neoplasms [ 15 ]. Misdiagnosis of neurofibromas is not uncommon.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of a Large Sinonasal Neurofibroma

Skalias¹,

Karamitsou²,

Poutoglidis³

et al. 2022

Cureus

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“…In the nasopharynx, the most common malignant lesion is the nasopharyngeal carcinoma (NPC), which is the known diagnostic term for all squamous cell carcinomas arising on the nasopharynx, however, there are some rare (unusual) epithelial and nonepithelial tumors appear in the nasopharynx including lymphoma, melanoma, salivary type malignancies, neurogenic tumors, nasopharyngeal papillary adenocarcinoma, and others [6,7] .…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal tumors with unusual presentations: a retrospective analysis from Saudi Arabia

Alzahrani

2024

International Journal of Surgery: Global Health

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The most common malignant lesion in the nasopharynx is the nasopharyngeal carcinoma (NPC), commonly presents with painless upper cervical lymphadenopathy secondary to nodal metastasis and the undifferentiated type is the most common diagnosis. Compared with other types of cancers, NPC is uncommon, albeit with a high difference in geographical distribution where the worldwide cases account for only 0.6% of all annually diagnosed cancers diagnosed, however, in Saudi Arabia the overall incidence among all age groups is 0.1–0.13 per 10 000. Other rare types of malignancies are also seen at the nasopharynx and due to the nonspecific clinical and imaging characteristics; the preoperative diagnosis may be difficult. This study retrospectively assessed the nasopharyngeal tumors diagnosed in a referral hospital in Al-Baha regions, Saudi Arabia during 10 years period that came with unusual presentations at the level of clinical, radiological, or pathological features to raise the awareness of healthcare provides by these entities. Twenty patients were included and revealed unusual (atypical) clinical presentation in 50% of case including a case presented with respiratory symptoms as a first presentation where multiple lung foci were seen and proved to be a metastatic NPC. Histopathological diagnoses were challenging for 40% of the cases revealing unusual malignant types. In summary, however, the nasopharyngeal malignancy is a rare entity, accurate diagnosis may be missed in clinical or even in the pathology examination. Surgeons and pathologists should be aware of the unusual presentation to provide early and more accurate diagnosis for such serous tumors.

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