Temperature and precipitation time series datasets from 1961 to 2005 at 65 meteorological stations were used to reveal the spatial and temporal trends of climate change in Xinjiang, China. Annual and seasonal mean air temperature and total precipitation were analyzed using Mann-Kendall (MK) test, inverse distance weighted (IDW) interpolation, and R/S methods. The results indicate that: (1) both temperature and precipitation increased in the past 45 years, but the increase in temperature is more obvious than that of precipitation;(2) for temperature increase, the higher the latitude and the higher the elevation the faster the increase, though the latitude has greater influence on the increase. Northern Xinjiang shows a faster warming than southern Xinjiang, especially in summer; (3) increase of precipitation occurs mainly in winter in northern Xinjiang and in summer in southern Xinjiang. Ili, which has the most precipitation in Xinjiang, shows a weak increase of precipitation; (4) although both temperature and precipitation increased in general, the increase is different inside Xinjiang; (5) Hurst index (H) analysis indicates that climate change will continue the current trends.