An Extranodal Site of Diffuse Large B-cell Lymphoma Presenting as Ovarian Cancer

Jaouani, Laila; Zaimi, A; Jarroudi, Ouissam Al; Berhili, Soufiane; Brahmi, Sami Aziz; Afqir, Saïd

doi:10.7759/cureus.34337

Cited by 4 publications

(5 citation statements)

References 29 publications

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“…The identi ed neoplasms generally exhibited a size exceeding 10 cm, manifesting as either an abdominal mass or an enlarged ovarian. Elevated levels of LDH and CA 125 were frequently observed, aiding in the diagnostic process and subsequent monitoring [10] . Other laboratory parameters and tumor markers generally were normal.…”

Section: Resultsmentioning

confidence: 99%

“…Until the lack of lymphoid tissue in normal ovaries has contributed to a lack of consensus regarding the tissue origin and pathogenesis of POL [10] . Some researchers hypothesize that chronic in ammatory stimulation of the ovary may play a role in the development of POLs, while others speculate that the lesions may arise from the lymphoid component of teratomas or malignant transformation of primitive reticular cells in the ovarian stroma [6,13] .…”

Section: Discussionmentioning

confidence: 99%

“…The presence of cysts at the periphery is indicative of ovarian lymphoma, which is not typically observed in bromas. Additionally, bromas demonstrate slower growth rates compared to lymphomas, which have the fastest doubling time of any tumor [10] . Rapid growth is a distinguishing feature more commonly associated with lymphoma than other ovarian neoplasms.…”

Section: Ovarian Bromamentioning

confidence: 99%

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The present state of primary ovarian lymphoma: a case report and twenty years of analysis

Liu,

Xu,

et al. 2024

Preprint

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Objective To analyze the clinical and imaging characteristics of primary ovarian lymphoma (POL) from the perspective of radiologists. Materials and Methods The clinical and imaging data of a 52-year-old patient diagnosed with POL was retrospectively analyzed in this study. A review and summary of similar cases reported in English over the past twenty years, as available in the PubMed database, were also conducted. Results The occurrence of POL is not limited by age but is more commonly observed in the forties years old. Clinical manifestations of POL are often nonspecific, presenting as an abdominal mass, abdominal pain, and ascites. The most prevalent histological subtype of POL is diffuse large B cell lymphoma. Imaging features are helpful for diagnosis, such as “ovarian retention sign”, “large ovaries touching each other”, and “vascular floatation”. Conclusion Imaging plays a crucial role in the diagnosis of POL, with radiologists serving as a pivotal role in furnishing essential diagnostic data to assist clinicians in devising suitable treatment strategies, preventing unnecessary surgical interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Ovarian Bromamentioning

confidence: 99%

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The present state of primary ovarian lymphoma: a case report and twenty years of analysis

Liu,

Xu,

et al. 2024

Preprint

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“…Given the lack of typical clinical findings in PFGLT patients, radiological or imaging studies have also been evaluated as useful diagnostic method [ 14 , 22 ]. Previous studies [ 7 , 23 ] showed that the main ultrasonographic manifestations of PLFGT were hypoechoic or extremely hypoechoic solid lesions that were relatively large in size (86.7% is greater than 5 cm), with clear boundaries and regular shapes, and ascites is rare.…”

Section: Discussionmentioning

confidence: 99%

Primary lymphoma of the female genital tract masquerading as gynecological malignancy

Shi,

Li,

et al. 2024

BMC Women's Health

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Background Primary lymphoma of the female genital tract (PLFGT) is a rare malignant tumor in the female reproductive system, with a low incidence and few clinical reports. The aim of this study is to report our institutional experience with this rare malignancy and emphasize the need for increasing the awareness about PLFGT presenting with gynecologic symptoms. Methods The medical records of patients diagnosed with PLFGT from March 2014 to November 2022 in the First Affiliated Hospital of Wannan Medical College were reviewed. Histological classification and staging were based on the World Health Organization and Ann Arbor systems, respectively. Results There were 13 patients with diagnosis of PLFGT and the median length of follow-up was 31 months (0-102 months). The main clinical symptoms included postmenopausal vaginal bleeding, pelvic mass and abdominal pain. Serum LDH increased in 10 patients and serum CA125 elevated in 2 patients. The tumor of ovarian or uterine presented as solid masses in CT or MRI, and ascites was rare. The histological subtypes were diffuse large B-cell (n = 12) and follicular (n = 1) lymphoma. Tumors were located in ovary (n = 8), uterus (n = 3), and cervix (n = 2). According to the Ann Arbor staging system, 6 cases were classified as stage II and 7 cases were classified as stage IV, respectively. A total of 10 patients underwent surgery. Combination chemotherapy was used in 10 patients. Eight patients had tumor-free survival, 1 patient had recurrent disease, 3 patients died and 1 patient lost to follow-up. The median survival time was 32 months (1-102 months). Conclusion PLFGT usually presents as gynecological symptoms and solid masses in pelvis. Surgery or biopsy was the way to obtain the pathologic diagnosis, and combination chemotherapy is the efficient method for PLFGT. Making an accurate preoperative diagnosis is of paramount importance to avoid radical gynecologic surgery.

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“…Although non-Hodgkin lymphomas may mimic other malignancies, many studies have proven the role of FDG PET/CT in diagnosis [15][16][17][18]. It is difficult to distinguish between ovarian lymphoma and ovarian epithelial malignancies due to the similarity of their clinical manifestations 19. The majority of extranodal lymphomas with ovarian involvement have a younger median age at diagnosis compared with ovarian epithelial malignancies 20,21.…”

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confidence: 99%

Unusual Presence of Synchronous Primary Ovarian and Thyroid Extranodal Non-Hodgkin Lymphoma Without Lymph Node Involvement

Babacan,

Acar Tayyar,

Şahin

et al. 2024

Clin Nucl Med

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Extranodal lymphomas without lymph node involvement are rarely observed and create diagnostic challenges. We present the case of a 33-year-old woman who was admitted with abdominal swelling. Ultrasonography findings suggested bilateral ovarian masses. 18F-FDG PET/CT revealed intense uptake on the bilateral pelvic mass and thyroid gland. Following excisional surgery and thyroid fine-needle aspiration biopsy, the patient was diagnosed with diffuse large B-cell lymphoma. This case is exceptionally rare, as it presents 2 synchronous extranodal involvements in the ovaries and the thyroid gland independently while not presenting any lymph node activity, which has not been reported before.

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An Extranodal Site of Diffuse Large B-cell Lymphoma Presenting as Ovarian Cancer

Cited by 4 publications

References 29 publications

The present state of primary ovarian lymphoma: a case report and twenty years of analysis

The present state of primary ovarian lymphoma: a case report and twenty years of analysis

Primary lymphoma of the female genital tract masquerading as gynecological malignancy

Unusual Presence of Synchronous Primary Ovarian and Thyroid Extranodal Non-Hodgkin Lymphoma Without Lymph Node Involvement

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