An Extramedullary Lesion in Multiple Myeloma: Voluminous Pericardial Mass

Franzese, Maria Grazia; Ieva, Riccardo; Correale, Michele; Palumbo, G A; Capalbo, Silvana

doi:10.1002/clc.20397

Cited by 3 publications

(4 citation statements)

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“…In terms of clinical symptoms, extramedullary intracardiac plasmacytoma can present with various signs and symptoms depending on the size and localization of the mass, such as pericardial tamponade, arrhythmia, SVC syndrome, or severe heart failure [ 4 , 6 ]. In this case, due to involvement of the left and right atrium as well as the extension to the SVS, the patient presented with bilateral pleural effusion and severe heart failure leading to an unstable hemodynamic state.…”

Section: Clinical Discussionmentioning

confidence: 99%

“…While plasmacytoma is usually a solitary tumor of the bone, EMP can occur in various extramedullary sites, such as the head and neck region [ 2 , 3 ]. Despite being rare, intracardiac EMPs can present with severe symptoms, including pericardial tamponade, arrhythmia, superior vena cava syndrome, and heart failure, and have a poor prognosis, with over 50 % of patients dying within 2 days to 15 months after diagnosis [ [4] , [5] , [6] ]. Diagnosing intracardiac EMP requires pathological investigation, which can be challenging due to the condition's rarity and difficulty distinguishing plasmacytoma from other, more common masses [ 2 ].…”

Section: Introduction and Importancementioning

confidence: 99%

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Uncommon manifestation of multiple myeloma: A case report of intracardiac plasmacytoma presenting with severe heart failure and bilateral pleural effusion

Mousavizadeh Ahmadabadi,

Banar,

Parvas

et al. 2024

International Journal of Surgery Case Reports

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Section: Clinical Discussionmentioning

confidence: 99%

Section: Introduction and Importancementioning

confidence: 99%

Uncommon manifestation of multiple myeloma: A case report of intracardiac plasmacytoma presenting with severe heart failure and bilateral pleural effusion

Mousavizadeh Ahmadabadi,

Banar,

Parvas

et al. 2024

International Journal of Surgery Case Reports

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“…Extramedullary cardiac plasmacytoma is extremely rare in patients with MM. Cardiac involvement of MM includes pericardial effusion [ 4 ], pericardial mass [ 5 ], intracardiac mass [ 2 , 3 , 6 , 7 ], and myocardial infiltration [ 8 , 9 ]. Extramedullary cardiac plasmacytoma may be either the initial or secondary presentation of MM [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…The clinical symptoms of extramedullary intracardiac MM are nonspecific, depending on the localization and size of the mass. Patients might present with pericardial tamponade, arrhythmia, SVC syndrome, or severe heart failure [ 5 , 10 ]. In this case, the large right atrial mass resulted in symptoms of SVC obstruction and right heart dysfunction in the patient.…”

Section: Discussionmentioning

confidence: 99%

Extramedullary intracardiac multiple myeloma misdiagnosed as a thrombus: a case report

Peng

Wang

2021

BMC Surg

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Background Extramedullary intracardiac multiple myeloma (MM) is extremely rare. Patients with extramedullary intracardiac MM may suffer from a poor prognosis. Experience in the diagnosis and therapy of cardiac involvement in MM is limited. Herein, we describe a 67-year-old male with extramedullary intracardiac MM who was initially misdiagnosed with a thrombus. Case presentation A 67-year-old male was admitted for exertional dyspnea and fatigue. The patient was diagnosed with MM one year earlier and had complete remission after chemotherapy. He was implanted with a permanent pacemaker two months prior due to sick sinus syndrome. After this admission, transthoracic echocardiography (TTE) and computed tomography (CT) confirmed the existence of a large right atrial mass extending to the superior and inferior vena cava. We initially considered the right atrial mass as a thrombus and performed surgical treatment for the patient. The surgical intervention partially relieved the obstruction of the superior and inferior vena cava and improved hemodynamics. Postoperative pathological examination of the right atrial mass suggested malignant plasmacytoma associated with MM. After recovery from the surgery, the patient received one cycle of chemotherapy. A follow-up of seven months revealed that our patient was still alive with a good general condition. Conclusions Increasing the awareness of extramedullary intracardiac lesions in patients with MM is warranted. Our case confirmed that surgical intervention followed by adjuvant chemotherapy could improve the patient’s hemodynamics and achieve remission of cardiac symptoms.

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Extraskeletal multiple myeloma presenting with an atrial mass: a case report and a review of the literature

et al. 2012

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IntroductionExtraskeletal presentation at diagnosis or during the course of multiple myeloma is a rare event. The prognosis is usually very poor. At the moment there is no agreed gold standard for the treatment of this presentation.Case presentationA 79-year-old Caucasian woman was treated at our hospital for right atrial myeloma localization. Our patient showed the following signs and symptoms of congestive heart failure: dyspnea, hypotension, cyanosis and facial edema. Surgery was not considered feasible due to the extent of the disease. Our patient underwent external-beam radiation therapy using an intensity modulated technique, thus obtaining a persistent complete remission. Our patient has been in continuous complete local remission for 25 months since the end of radiotherapy.ConclusionThe role of radiotherapy is not defined in multiple myeloma with extraskeletal presentation. Our regimen seems to be effective in controlling the disease in this patient.This case report adds to the existing literature as it describes an unusual presentation of the disease and a new therapeutic approach to this rare presentation of multiple myeloma.

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An Extramedullary Lesion in Multiple Myeloma: Voluminous Pericardial Mass

Cited by 3 publications

References 1 publication

Uncommon manifestation of multiple myeloma: A case report of intracardiac plasmacytoma presenting with severe heart failure and bilateral pleural effusion

Uncommon manifestation of multiple myeloma: A case report of intracardiac plasmacytoma presenting with severe heart failure and bilateral pleural effusion

Extramedullary intracardiac multiple myeloma misdiagnosed as a thrombus: a case report

Extraskeletal multiple myeloma presenting with an atrial mass: a case report and a review of the literature

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