Abstract:Metastatic relapse can occur months to years after the cancer is first diagnosed, and it relies on the reactivation of disseminated tumour cells (DTCs) that have lied dormant in secondary organs. The acquisition and maintenance of a dormancy phenotype are tightly regulated by the interaction of DTCs with their microenvironment. In the bone, the dormant program activated in metastatic competent cells and how their reactivation is induced are largely unknown. We here present a strategy to engineer a mouse-to-mou… Show more
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