This paper critically analysis the definition of smart specialisation priority areas of Romanian less developed regions, aiming to identify weaknesses in policy design that according to existing theories characterise such regions. Besides an empirical contribution to the literature, findings also have a practical relevance. They can be used by regions to redesign strategies in their preparation for the absorption of Cohesion Policy funds between 2021 and 2027. While in the definition of priority areas we could depict resemblance with the general practice presented in the literature, there are also shortcomings reported to the evaluation framework proposed in this paper based on official methodological and original theoretical aspects. These mainly refer to a less targeted approach within priorities, overlapping between priorities and horizontal character of vertically defined priorities. However, under these aspects, regional strategies present a high level of heterogeneity; thus, responsible institutions will need to invest different time and effort to revise policy documents.