An extensive projection of fish dorsolateral tegmental cells to the optic tectum revealed by intra-axonal dye marking

Niida, Akiyoshi; Ohono, Takashi

doi:10.1016/0304-3940(84)90048-x

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…The present data are consistent with that study and add the notion that the tectal target of the MRF axons is primarily within the intermediate and deep layers of the ipsilateral tectum, with some axons reaching these layers in the contralateral tectum. These findings are in agreement with those reported form intracellular labeling of MRF neurons in goldfish (Niida and Ohono,1984). These ipsilateral and contralateral tectal layers have also been found to be the target of MRF neurons in reptiles, based on extracellular injections, and in monkeys, based on intracellular injections (Dacey and Ulinski,1986; Moschovakis et al,1988).…”

Section: Discussionsupporting

confidence: 93%

Connections of eye‐saccade‐related areas within mesencephalic reticular formation with the optic tectum in goldfish

Luque

Pérez-Pérez

Herrero

et al. 2006

J of Comparative Neurology

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Physiological studies demonstrate that separate sites within the mesencephalic reticular formation (MRF) can evoke eye saccades with different preferred directions. Furthermore, anatomical research suggests that a tectoreticulotectal circuit organized in accordance with the tectal eye movement map is present. However, whether the reticulotectal projection shifts with the gaze map present in the MRF is unknown. We explored this question in goldfish, by injecting biotin dextran amine within MRF sites that evoked upward, downward, oblique, and horizontal eye saccades. Then, we analyzed the labeling in the optic tectum. The main findings can be summarized as follows. 1) The MRF and the optic tectum were connected by separate axons of the tectobulbar tract. 2) The MRF was reciprocally connected mainly with the ipsilateral tectal lobe, but also with the contralateral one. 3) The MRF received projections chiefly from neurons located within intermediate and deep tectal layers. In addition, the MRF projections terminated primarily within the intermediate tectal layer. 4) The distribution of labeled neurons in the tectum shifted with the different MRF sites in a manner consistent with the tectal motor map. The area containing these cells was targeted by a high-density reticulotectal projection. In addition to this high-density topographic projection, there was a low-density one spread throughout the tectum. 5) Occasionally, boutons were observed adjacent to tectal labeled neurons. We conclude that the organization of the reticulotectal circuit is consistent with the functional topography of the MRF and that the MRF participates in a tectoreticulotectal feedback circuit.

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Section: Discussionsupporting

confidence: 93%

Connections of eye‐saccade‐related areas within mesencephalic reticular formation with the optic tectum in goldfish

Luque

Pérez-Pérez

Herrero

et al. 2006

J of Comparative Neurology

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“…Such a projection has been previously reported in fish (Grover & Sharma, 1981;Luiten, 1981;Northcutt, 1982;Smeets, 1982;Fiebig et al, 1983;Niida & Ohono, 1984;Schlussman et al, 1990). The mesencephalic reticular formation is involved in the generation of eye and body movements in fish (Demski, 1982(Demski, , 1983Bernau et al, 1991;Fetcho & Svoboda, 1993;Uematsu & Todo, 1997) as in other vertebrate species (Cohen et al, 1985;Masino & Knudsen, 1993;Waitzman et al, 2000a,b).…”

Section: Location Of Tectal Afferentsmentioning

confidence: 80%

Afferent connectivity to different functional zones of the optic tectum in goldfish

et al. 2003

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This work studies the afferent connectivity to different functionally identified tectal zones in goldfish. The sources of afferents contributed to different degrees to the functionally defined zones. The dorsocentral area of the telencephalon was connected mainly with the ipsilateral anteromedial tectal zone. At diencephalic levels, neurons were found in three different regions: preoptic, thalamic, and pretectal. Preoptic structures (suprachiasmatic and preoptic nuclei) projected mainly to the anteromedial tectal zone, whereas thalamic (ventral and dorsal) and pretectal (central, superficial, and posterior commissure) nuclei projected to all divisions of the tectum. In the mesencephalon, the mesencephalic reticular formation, torus longitudinalis, torus semicircularis, and nucleus isthmi were, in the anteroposterior axis, topographically connected with the tectum. In addition, neurons in the contralateral tectum projected to the injected zones in a symmetrical point-to-point correspondence. At rhombencephalic levels, the superior reticular formation was connected to all studied tectal zones, whereas medial and inferior reticular formations were connected with medial and posterior tectal zones. The present results support a different quantitative afferent connectivity to each tectal zone, possibly based on the sensorimotor transformations that the optic tectum carries out to generate orienting responses.

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“…We propose DLT and FRL as potential targets based on evidence that these brain regions receive visual inputs from the ipsilateral tectobulbar tract in adult teleost fish (Grover & Sharma, ). In the carp, DLT has been shown to form an extensive feedback projection to ipsilateral tectum (Niida & Ohono, ), similar to that from NI. The possibility that TGPN projections to NI and/or DLT form components of an attentional circuit in the larval fish could be tested in the future using the id2b : gal4 transgenic to target these cells for functional imaging and optogenetic manipulation.…”

Section: Discussionmentioning

confidence: 99%

“…Ipsilaterally, two main visual output areas have been identified: nucleus of the DLT and lateral reticular formation (FRL). Notably, DLT is a visually responsive structure reciprocally connected with optic tectum in goldfish (Niida & Ohono, ). In the larval zebrafish, a pan‐tectal transgenic gal4 line has been used to generate single cell labeling of tectobulbar neurons that innervate the mesencephalic and rhombencephalic premotor areas (Helmbrecht et al, ).…”

Section: Introductionmentioning

confidence: 99%

Neuron types in the zebrafish optic tectum labeled by an id2b transgene

DeMarco

Baier

et al. 2019

J of Comparative Neurology

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The larval zebrafish optic tectum has emerged as a prominent model for understanding how neural circuits control visually guided behaviors. Further advances in this area will require tools to monitor and manipulate tectal neurons with cell type specificity. Here, we characterize the morphology and neurotransmitter phenotype of tectal neurons labeled by an id2b:gal4 transgene. Whole‐brain imaging of stable transgenic id2b:gal4 larvae revealed labeling in a subset of neurons in optic tectum, cerebellum, and hindbrain. Genetic mosaic labeling of single neurons within the id2b:gal4 expression pattern enabled us to characterize three tectal neuron types with distinct morphologies and connectivities. The first is a neuron type previously identified in the optic tectum of other teleost fish: the tectal pyramidal neuron (PyrN). PyrNs are local interneurons that form two stratified dendritic arbors and one stratified axonal arbor in the tectal neuropil. The second tectal neuron type labeled by the id2b:gal4 transgene is a projection neuron that forms a stratified dendritic arbor in the tectal neuropil and an axon that exits tectum to form a topographic projection to torus longitudinalis (TL). A third neuron type labeled is a projection neuron with a nonstratified dendritic arbor and a descending axonal projection to tegmentum. These findings establish the id2b:gal4 transgenic as a useful tool for future studies aimed at elucidating the functional role of tectum, TL, and tegmentum in visually guided behaviors.

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An extensive projection of fish dorsolateral tegmental cells to the optic tectum revealed by intra-axonal dye marking

Cited by 13 publications

References 9 publications

Connections of eye‐saccade‐related areas within mesencephalic reticular formation with the optic tectum in goldfish

Connections of eye‐saccade‐related areas within mesencephalic reticular formation with the optic tectum in goldfish

Afferent connectivity to different functional zones of the optic tectum in goldfish

Neuron types in the zebrafish optic tectum labeled by an id2b transgene

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