2008
DOI: 10.1210/en.2008-0868
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An Extensive Genetic Program Occurring during Postnatal Growth in Multiple Tissues

Abstract: Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified more than 1600 genes that were regulated with age (1 vs. 4 wk) coordinately in kidney, lung, and heart of male mice, including many genes that regulate proliferation. As … Show more

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Cited by 70 publications
(95 citation statements)
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“…16 Smarca1 expression has been reported to decrease with age in developing heart, kidney and lung. 17 Given that chromatin remodeling complexes potently regulate endocrine pancreas development, 18 it seems likely that Smarca1 might influence b-cell growth or regeneration. Top2a expression was also present in greater amounts in young islets (3.5-4.5 fold).…”
Section: Resultsmentioning
confidence: 99%
“…16 Smarca1 expression has been reported to decrease with age in developing heart, kidney and lung. 17 Given that chromatin remodeling complexes potently regulate endocrine pancreas development, 18 it seems likely that Smarca1 might influence b-cell growth or regeneration. Top2a expression was also present in greater amounts in young islets (3.5-4.5 fold).…”
Section: Resultsmentioning
confidence: 99%
“…This phenomenon has also been shown to occur in rodent models (Finkielstein et al 2009); however, the pattern of human growth and development is distinct from that of other mammals (Bogin 1999, Thompson & Nelson 2011, and is characterised by rapid but decelerating growth in infancy, an extended childhood phase of slow growth and a pubertal growth spurt before final height is reached, termed the infancy-childhood-puberty growth model (Karlberg et al 2003). Despite extensive experience over the past 25 years in the clinical management of growth failure in growth disorders, including growth hormone deficiency (GHD) and Turner syndrome (TS), predicting treatment efficacy in individual children remains a significant challenge as both age and stage of childhood development are now known to be important predictors of the outcome of treatments (Ranke et al 1999, Ranke et al 2000, Ranke & Lindberg 2011, Patel & Clayton 2012, Ranke 2013).…”
Section: Human Growth and Short Stature In Childhoodmentioning
confidence: 71%
“…This claim is supported by Finkielstain et al [16]. Lui and Baron [15] further elaborate that the local communication mechanisms play a central role in growth deceleration rather than the systemic mechanism.…”
mentioning
confidence: 74%