An extensive discrepancy in myocardial uptake of thallium-201 and iodine-123 BMIPP in a patient with ST-segment elevation myocardial infarction treated using postconditioning with lactate-enriched blood

Koyama, Takashi; Munakata, Masahito; Ashihara, Takashi; Kanki, Hideaki; Ishikawa, Shiro

doi:10.1016/j.ijcard.2015.06.143

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Figure 4 shows a coronary angiogram before and after the completion of PCI using PCLeB and dual-loading scintigraphy with thalium-201 and iodine-123 BMIPP before discharge, as previously reported in a representative case presentation [ 57 ]. A 65-year-old male patient, presenting with 5 h of prolonged chest pain, underwent coronary angiography, which revealed total occlusion of the proximal right coronary artery with second-degree collateral circulation supplied by the left coronary artery.…”

Section: Postconditioning With Lactate-enriched Blood (Pcleb)mentioning

confidence: 79%

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Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans

Koyama

2023

J. of Cardiovasc. Trans. Res.

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Ischemic myocardium cannot survive without reperfusion. However, reperfusion of the ischemic myocardium paradoxically induces myocyte death; this phenomenon is termed lethal reperfusion injury. To date, no effective approach has been demonstrated for ST-segment elevation myocardial infarction (STEMI) in clinical settings. Recently, we demonstrated a novel approach for cardioprotection, termed postconditioning with lactate-enriched blood (PCLeB). PCLeB comprises intermittent reperfusion and timely coronary injections of lactated Ringer’s solution, which is implemented at the beginning of reperfusion. This approach is aimed at reducing lethal reperfusion injury via prolonging intracellular acidosis during the early period of reperfusion, compared with the original postconditioning protocol. Patients with STEMI treated using PCLeB have reported positive outcomes. This article represents an effort, with a perspective different from current insights, toward preventing lethal reperfusion injury, in light of the historical background of reperfusion injury research. PCLeB is considered the new approach for cardioprotection. Graphical Abstract

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Section: Postconditioning With Lactate-enriched Blood (Pcleb)mentioning

confidence: 79%

“…The take-up of thallium by the myocardium supplied by the RCA was excellent, in stark contrast to the large defect observed in BMIPP imaging. Reprinted from Koyama et al [ 57 ] …”

Section: Postconditioning With Lactate-enriched Blood (Pcleb)mentioning

confidence: 99%

Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans

Koyama

2023

J. of Cardiovasc. Trans. Res.

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“…Knapp introduced the BMIPP tracer into clinical practice in 1986 [83]. In 1989 Ogata reported experimental data suggesting that adriamycin induced mitochondrial function impairment by decreasing myocardial uptake of BMIPP in rats, while heart perfusion evaluated with 201 Tl, was uneventful compared to the control group [84]. The author had administered 4mg/kg of adriamycin intraperitoneally for six days.…”

Section: The Use Of Nuclear Medicine Diagnostic Imaging To Visualize ...mentioning

confidence: 99%

“…The imaging studies showed a decrease in accumulation of both 18 F-FDG and BMIPP [85]. Both experimental and clinical data have described low uptake of BMIPP following administration of adriamycin [84,86]. Loss of cardiac function due to doxorubicin has been described in cell culture using 99m Tc-Sestamibi A functional relation between BMIPP and doxorubicin toxicity was described by Saito et al in 2000 using a quantitative method for the determination of the k-value of tracer uptake [90].…”

Section: The Use Of Nuclear Medicine Diagnostic Imaging To Visualize ...mentioning

confidence: 99%

Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity by Nuclear Medicine Diagnostic Imaging With 18F-Flurodeoxyglucose – Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dysfunction

Moncayo,

Moncayo

2024

Preprint

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Cardiotoxicity is an unwanted side-effect arising from different medications. The term describes a diminution of heart function, affecting especially left ventricular ejection fraction, which can progress to heart failure. Pediatric oncology patients treated with drugs of the anthracycline group, e.g., doxorubicin, can evolve to heart failure patients in adult age. Nuclear Medicine imaging of fatty acid oxidation and glycolysis accurately describes normal and altered heart metabolism. The most common finding is a state of cardiac glycolysis, which is reflected by increased uptake of 18F-desoxyglucose (18F-FDG) at a time when fatty acid oxidation is decreased. Glycolysis has recently been recognized as being the result of coenzyme Q10 deficiency as part of adaptation to hypoxia. Low LEVF correlates with impaired fatty acid oxidation. This deficiency can arise from chemotherapy and radiation and can be corrected by supplementation. Drugs like enalapril can improve fatty acid utilization. We will review relevant Nuclear Medicine imaging studies as well as fundamental biochemical data that demonstrate this pathogenetic path.

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Minimum ischemia–reperfusion injury in a STEMI patient treated using postconditioning with lactate-enriched blood

Munakata

Koyama

Ashihara

et al. 2016

International Journal of Cardiology

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An extensive discrepancy in myocardial uptake of thallium-201 and iodine-123 BMIPP in a patient with ST-segment elevation myocardial infarction treated using postconditioning with lactate-enriched blood

Cited by 3 publications

References 4 publications

Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans

Postconditioning with Lactate-Enriched Blood for Reducing Lethal Reperfusion Injury in Humans

Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity by Nuclear Medicine Diagnostic Imaging With 18F-Flurodeoxyglucose – Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dysfunction

Minimum ischemia–reperfusion injury in a STEMI patient treated using postconditioning with lactate-enriched blood

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