An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda

Al-Shehri, Hajri; Stanton, Michelle C.; LaCourse, E. James; Atuhaire, Aaron; Arinaitwe, Moses; Wamboko, Aida; Adriko, Moses; Kabatereine, Narcis B.; Stothard, J. Russell

doi:10.1093/trstmh/trw072

Cited by 24 publications

(48 citation statements)

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“…Epidemiological data previously collected within this region provided a useful foundation and thereby influenced the selection of schools for our study. 27,32,33 Buliisa is bordered by Nebbi (north), Masindi (east), Hoima (south), and the Democratic Republic of Congo (west). Biiso and Busingiro lay at altitudes of 1,004 and 1,062 m, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Egg patent S. mansoni infection prevalences among children aged 5-10 years in the villages of Bugoigo, Walukuba, Biiso, and Busingiro have been previously identified to be 36.7%, 82.0%, 19.7%, and 8.0% respectively. 27 No transmission of S. haematobium has been documented on parasitological surveys in the field of study. 27,34 The study involved 305 schoolchildren aged 7-15 years.…”

Section: Methodsmentioning

confidence: 99%

“…27 No transmission of S. haematobium has been documented on parasitological surveys in the field of study. 27,34 The study involved 305 schoolchildren aged 7-15 years. Of the 305 schoolchildren, a total of 96 children from Biiso, Busingiro, and Bugoigo Islamic schools were followed up from 2 weeks prior.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies have identified egg patent S. mansoni infection prevalences of up to 82% among children aged 5-10 years living in the region. 27 Since 2004, the control of schistosomiasis-related morbidity in Uganda has been centered on the targeted, periodic distribution of praziquantel therapy to school-aged children older than 4 years and selected "at risk" adult populations. 28 Proxy markers of morbidity have since been evaluated, including fecal occult blood, anemia, and fecal calprotectin testing, quality of life questionnaires, biometry, clinical palpation and measurement, portable ultrasonography, and fitness tests.…”

Section: Introductionmentioning

confidence: 99%

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Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children

Smith

McLachlan

Shehri

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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Using the 20-meter shuttle run test (20mSRT) as a morbidity metric, we assessed whether Schistosoma mansoni infection was associated with decreased aerobic capacity in Ugandan children across a range of altitudes, either at low (∼600 m) or high (∼1,000 m) altitudes. A total of 305 children were recruited from six schools within the Buliisa District, Lake Albert, Uganda. A subset (n = 96) of these had been previously assessed and treated for schistosomiasis ± malaria 2 weeks prior. Fitness scores on the 20mSRT were translated into VO2max using a standardized equation. Unadjusted and multivariable-adjusted analyses were performed using VO2max as the primary outcome. Analysis of fitness scores from 304 children, inclusive of the subset follow-up cohort, revealed a median VO2max of 45.4 mL kg −1 min −1 (interquartile range: 42.9-48.0 mL kg −1 min −1 ). Children residing at high altitudes demonstrated increased aerobic capacities (46.3 versus 44.8 mL kg −1 min −1 , P = 0.031). The prevalence of stunting, wasting, S. mansoni egg patent infection, malaria, giardiasis, anemia, and fecal occult blood were 36.7%, 16.1%, 44.3%, 65.2%, 21.4%, 50.6%, and 41.2%, respectively. Median VO2max was elevated in those previously treated, compared with those newly recruited (46.3 versus 44 mL kg −1 min −1 , P < 0.001). Multivariable-adjusted analysis revealed a strong negative association between S. mansoni egg patent infection and VO2max at low altitude (beta coefficient: −3.96, 95% CI: −6.56 to −137, P = 0.004). This is the first study to document a negative association between S. mansoni infection and aerobic capacity at low altitudes using the 20mSRT.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children

Smith

McLachlan

Shehri

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…Foi encontrada associação significativa entre anemia e infecção por enteroparasitos, assim como de práticas inadequadas de lavagem das mãos e defecação em locais abertos 25 . Al-Shehri et al 26 também descreveram a associação significativa entre anemia e infecção por G. lamblia em um estudo realizado com 254 crianças de Uganda.…”

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Prevalência de anemia associada a parasitoses intestinais no território brasileiro: uma revisão sistemática

Moraes

Andrade

Farias

et al. 2020

Revista Pan-Amazônica de Saúde

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Estimar a prevalência de anemia associada a parasitoses intestinais, assim como identificar os parasitos mais frequentes, a faixa etária mais acometida e os fatores relacionados ao desenvolvimento. MÉTODOS: Trata-se de uma revisão sistemática descritiva, com base no modelo PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), incluindo artigos publicados entre 2014 e 2018, nos idiomas inglês e português, a partir da busca nas bases de dados Google Acadêmico, PubMed (National Library of Medicine) e Biblioteca Virtual em Saúde Brasil, utilizando a combinação dos descritores "prevalência de anemia associada a parasitoses, Brasil". Após análises independentes de três revisoras, foram excluídos artigos de revisão, artigos experimentais com animais, casos clínicos, artigos pagos, artigos duplicados nos bancos, estudos relacionando anemia com outras doenças, descrevendo a presença apenas de anemias ou de parasitoses. RESULTADOS: Foram encontrados 1.697 artigos nas bases de dados, dos quais 10 foram selecionados e demonstraram associação média de anemia e parasitoses intestinais de 11,4% na Região Sul, 13,1% na Região Nordeste e 3,5% na Região Centro-Oeste; na Região Norte, não foi realizada associação estatística. Dentre os parasitos mais frequentes, destacaram-se: Entamoeba coli, Giardia lamblia e Endolimax nana. A maioria dos estudos foi realizada em crianças e adolescentes de até 14 anos de idade. CONCLUSÃO: Os achados deste estudo mostraram que a prevalência de anemia associada a parasitoses, no Brasil, é significativa quando há maior frequência de parasitos patogênicos na população estudada, reforçando a necessidade de realização de estudos amplos de prevalência.

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Anémie aiguë de cause rare en France métropolitaine. À propos d’un cas de coinfection par Trichuris trichiura et Giardia intestinalis chez un adolescent de 12 ans

Rouau

Kayemba-Kay’s

2022

Journal de Pédiatrie et de Puériculture

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An extensive burden of giardiasis associated with intestinal schistosomiasis and anaemia in school children on the shoreline of Lake Albert, Uganda

Abstract: Background: Water-borne parasitic diseases associated with poverty still blight the lives of African

Cited by 24 publications

References 40 publications

Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children

Schistosoma mansoni Infection as a Predictor of Low Aerobic Capacity in Ugandan Children

Prevalência de anemia associada a parasitoses intestinais no território brasileiro: uma revisão sistemática

Anémie aiguë de cause rare en France métropolitaine. À propos d’un cas de coinfection par Trichuris trichiura et Giardia intestinalis chez un adolescent de 12 ans

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