An extensible lattice Boltzmann method for viscoelastic flows: complex and moving boundaries in Oldroyd-B fluids

Kuron, Michael; Stewart, C. L.; Graaf, Joost de; Holm, Christian

doi:10.1140/epje/s10189-020-00005-6

Cited by 17 publications

(3 citation statements)

References 86 publications

(183 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The density of multiciliated cells (MCC) was evaluated with the average pixel density of the fluorescence associated to cilia staining as previously described [ 10 ]. The percentage of primary ciliated cells and the average cilia length were automatically quantified with CiliaQ as previously described [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

et al. 2021

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However, its pathophysiology remains partially elucidated. Epithelial remodeling including alteration of the cilium is a major hallmark of COPD, but specific assessments of the cilium have been rarely investigated as a diagnostic tool in COPD. Here we explore the dysregulation of the ciliary function (ciliary beat frequency (CBF)) and differentiation (multiciliated cells formation in air-liquid interface cultures) of bronchial epithelial cells from COPD (n = 17) and non-COPD patients (n = 15). CBF was decreased by 30% in COPD (11.15 +/− 3.37 Hz vs. 7.89 +/− 3.39 Hz, p = 0.037). Ciliary differentiation was altered during airway epithelial cell differentiation from COPD patients. While the number of multiciliated cells decreased (p < 0.005), the number of primary ciliated cells increased (p < 0.05) and primary cilia were shorter (p < 0.05). Altogether, we demonstrate that COPD can be considered as a ciliopathy through both primary non-motile cilia modifications (related to airway epithelial cell repair and remodeling) and motile cilia function impairment (associated with decrease sputum clearance and clinical respiratory symptoms). These observations encourage considering cilia-associated features in the complex COPD physiopathology and highlight the potential of cilia-derived biomarkers for diagnosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The crack growth behavior at other displacement rates is similar and hence is not further discussed. Analytical models could be considered to analyze interfacial failure in the future [ 2 , 20 , 48 , 49 ].…”

Section: Numerical Modelingmentioning

confidence: 99%

Displacement Rate Effects on the Mode II Shear Delamination Behavior of Carbon Fiber/Epoxy Composites

et al. 2021

View full text Add to dashboard Cite

This paper studies the influence of displacement rate on mode II delamination of unidirectional carbon/epoxy composites. End-notched flexure test is performed at displacement rates of 1, 10, 100 and 500 mm/min. Experimental results reveal that the mode II fracture toughness GIIC increases with the displacement, with a maximum increment of 45% at 100 mm/min. In addition, scanning electron micrographs depict that fiber/matrix interface debonding is the major damage mechanism at 1 mm/min. At higher speeds, significant matrix-dominated shear cusps are observed contributing to higher GIIC. Besides, it is demonstrated that the proposed rate-dependent model is able to fit the experimental data from the current study and the open literature generally well. The mode II fracture toughness measured from the experiment or deduced from the proposed model can be used in the cohesive element model to predict failure. Good agreement is found between the experimental and numerical results, with a maximum difference of 10%. The numerical analyses indicate crack jump occurs suddenly after the peak load is attained, which leads to the unstable crack propagation seen in the experiment.

show abstract

“…More information about these aspects can be found in Refs. [4][5][6][7][8][9][10][11][12] of this Topical Issue.…”

mentioning

confidence: 99%

Editorial: Motile active matter

et al. 2021

View full text Add to dashboard Cite

An extensible lattice Boltzmann method for viscoelastic flows: complex and moving boundaries in Oldroyd-B fluids

Cited by 17 publications

References 86 publications

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD

Displacement Rate Effects on the Mode II Shear Delamination Behavior of Carbon Fiber/Epoxy Composites

Editorial: Motile active matter

Contact Info

Product

Resources

About