“…Outside this core region, deleterious p53 changes tend to be nonsense or frameshift mutations that cause premature protein translation termination (Ishioka et al, 1995;Hainaut et al, 1997;Beroud and Soussi, 1998;Sedlacek et al, 1998). In addition, mutations that cause alternate splicing of precursor mRNA have been described in six LFS kindreds (Warneford et al, 1992;Felix et al, 1993;Jolly et al, 1994;Frebourg et al, 1995;Varley et al, 1997bVarley et al, , 1998a. In this study we describe three additional LFS families with inherited p53 splice site mutations.…”