An Extended Duration of the Pre-Operative Hospitalization is Associated with an Increased Risk of Healthcare-Associated Infections after Cardiac Surgery

Abstract

Nosocomial infections are a common complication in clinical practice with major impact on surgical success and patient outcome. The probability of nosocomial infections is rapidly increasing during hospitalization. Therefore, we investigated the impact of a prolonged pre-operative hospital stay on the development of post-operative infection. Within this prospective observational study, 200 patients scheduled for elective cardiac surgery were enrolled. Patients were followed during hospital admission and screened for the development of nosocomial infection. Logistic regression analysis was used to assess the impact of a prolonged pre-operative hospital stay on the development of infection. A total of 195 patients were suitable for the final analysis. We found a strong and direct association of the duration of pre-operative hospital stay and the number of patients developing infection (+23.5%; p = 0.006). Additionally, the length of patients' pre-operative hospital stay was independently associated with the development of post-operative nosocomial infection, with an adjusted OR per day of 1.38 (95%CI: 1.02-1.86; p = 0.036). A prolonged pre-operative hospital stay was significantly associated with the development of nosocomial infection after cardiac surgery. Those findings need to be considered in future clinical patient management in order to prevent unnecessary antibiotic use and potential harm to patients.

Nosocomial Outbreak of SARS-CoV-2 in a Non-COVID Zone of a Tertiary Care Hospital of North India: Need to Upgrade Infection Control Practices

“…Various studies have found longer duration of stay in hospital and nosocomial infections among patients. 13 , 14 The COVID-19 positivity among the patients admitted in the hospital for some non-COVID related etiology indicate nosocomial/hospital acquired infection as found in our current study. This is similar to the reports of acquiring COVID-19 infection among non-COVID patients from other hospitals settings where nosocomial infections have been reported.…”

Retrospective Study of Nosocomial Infections in the Orthopaedic and Rehabilitation Clinic of the Medical University of Lublin in the Years 2018–2020

“…However, it can be seen that the highest number of infections was observed in the first stay, where the largest number of patients were hospitalized but in the period of hospitalization over 181 days, when fewer patients were hospitalized the number of infections was the highest, which suggests that the duration of hospitalization increases the risk of developing NI. In studies conducted by Sulzgruber et al, it can also be noted that the frequency of nosocomial infections associated with postoperative care increased significantly with the length of the patient's pre-operative hospitalization [25].…”

Infección temprana de la malla quirúrgica en herniorrafia incisional. Incidencia, factores de riesgo y desenlaces en más de 60.000 pacientes

“…Otros factores clínico-quirúrgicos presentaron una asociación significativa con el riesgo de infección temprana en el presente estudio, como el tiempo desde el ingreso hospitalario hasta el procedimiento quirúrgico, el cual ha sido identificado como un factor asociado a un mayor riesgo de infecciones de sitio operatorio en otros contextos [47][48][49][50] . Su asociación con este desenlace puede derivar de una mayor exposición a patógenos nosocomiales y a la depleción nutricional secundaria al ayuno prolongado en espera de la realización del procedimiento quirúrgico, entre otros 47 .…”