An extended cell-average technique for a multi-dimensional population balance of granulation describing aggregation and breakage

Chaudhury, Anwesha; Kapadia, Avi; Prakash, Anuj; Barrasso, Dana; Ramachandran, Rohit

doi:10.1016/j.apt.2013.01.006

Cited by 46 publications

(25 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since a non-linear grid was used, most daughter particles from aggregation and breakage have solid volumes that fall between bins. The cell average method was used to allocate these particles [18,19]. The coupled ODEs were solved using first-order Euler integration with a variable step size.…”

Section: Methodsmentioning

confidence: 99%

Multi-dimensional population balance model development and validation for a twin screw granulation process

et al. 2015

Self Cite

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Multi-dimensional population balance model development and validation for a twin screw granulation process

et al. 2015

Self Cite

View full text Add to dashboard Cite

“…However, as mentioned in Section 3.1, the grid of particle sizes used for developing the PBM is exponential in nature. Therefore, the number of particles was allocated in the appropriate grid locations, and the cell average technique as developed in [35] was employed where lever rule techniques are used to distribute particles in nearest grid locations by linear interpolations.…”

Section: Numerical Techniquesmentioning

confidence: 99%

Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology

et al. 2018

Self Cite

View full text Add to dashboard Cite

An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composition in the formulation. A population balance model framework integrated with heat transfer and moisture balance due to liquid addition and evaporation was developed to simulate the fluid bed granulation system. The model predictions were compared with the industry data, namely, the particle size distributions (PSDs) and geometric mean diameters (GMDs) at various time-points in the granulation process. The model also predicted the trends for binder particle dissolution in the wetting liquid and the temperatures of the bed particles in the fluid bed granulator. Lastly, various process parameters were varied and extended beyond the region studied in the aforementioned experimental study to identify optimal regimes for granulation.

show abstract

“…A linear grid requires a large number of bins to span a certain size range. However a nonlinear grid can span the same range using fewer bins, thus reducing the computational overhead [17]. Various algorithms have been developed to implement a nonlinear grid for discretization [14,40,41,49].…”

Section: Numerical Techniques To Solve Population Balance Modelsmentioning

confidence: 99%

Population Balance Models for Pharmaceutical Processes

Chaudhury

Sen

Barrasso

et al. 2016

Methods in Pharmacology and Toxicology

Self Cite

View full text Add to dashboard Cite

The pharmaceutical industry is predominantly dominated by the handling of particulate matter in the form of solids and emulsions. With the enforcement of the Quality by Design (QbD) initiative by the Food and Drug Association (FDA), a process systems engineering based case toward particulate process design is advantageous. This suggests the need for mechanistic modeling approaches that can be used for an accurate representation of the process dynamics. The inherent discrete nature of population balance models (PBM) makes it an appropriate framework for modeling particulate processes. With the representation of the particulate processes used for pharmaceutical product manufacturing using various modeling frameworks, advancements can be made to improved control and optimization of the process. This chapter provides a detailed review on the applicability and significance of PBMs in drug product manufacturing and is aimed to provide greater insight into the field of process systems engineering.

show abstract

An extended cell-average technique for a multi-dimensional population balance of granulation describing aggregation and breakage

Cited by 46 publications

References 58 publications

Multi-dimensional population balance model development and validation for a twin screw granulation process

Multi-dimensional population balance model development and validation for a twin screw granulation process

Model Development and Validation of Fluid Bed Wet Granulation with Dry Binder Addition Using a Population Balance Model Methodology

Population Balance Models for Pharmaceutical Processes

Contact Info

Product

Resources

About