An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes

Waeytens, Ruben; Souter, L De; Grymonpré, W.; Hauwermeiren, Daan Van; Beer, Thomas De

doi:10.1016/j.ijpharm.2022.122154

Cited by 4 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Waeytens et al developed an extensive model to describe mixing behaviours inside twin-screw feeders at different refill regimes. [153] Additional studies seek to create new devices for optimal mixing under unique process conditions. One example is in the field of nanomedicine.…”

Section: Blending and Mixingmentioning

confidence: 99%

See 1 more Smart Citation

Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives

Hyer,

Gregory,

Kay

et al. 2024

Adv Synth Catal

View full text Add to dashboard Cite

The pharmaceutical industry has traditionally employed batch processing as a means of synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch manufacturing enables API synthesis in large quantities in order to meet regulations. Yet, this strategy remains cumbersome, is labor‐intensive, and creates complex logistical networks. In recent decades, batch API processing has gradually eroded American economic competitiveness and has led to the off‐shoring of API manufacturing from the United States. Today it is estimated that +80% of APIs are manufactured overseas. Meanwhile, disruptions from the Coronavirus Disease (SARS‐CoV‐2) have exacerbated weaknesses in the global supply chain, culminating with widespread shortages of critical life‐saving drugs. These shortages have emphasized the importance of reshoring drug manufacturing to the U.S. and fostered a regulatory landscape that seeks advanced methods of API manufacturing in order to bolster America’s supply chain resiliency. Recently, increased attention has been directed towards continuous drug manufacturing to enable nonstop API production within modular stand‐alone flow systems. Continuous manufacturing (CM) facilitates modular automation, offers new avenues towards process intensification, and even enables in‐line analytical monitoring from raw materials to packaged products. This strategy offers better conversion, increased safety, reduced waste, and overall cost savings versus traditional batch‐style processing. The rise of advanced API manufacturing, coupled with the current regulatory landscape, offers a rare window of opportunity to convert traditional batch pharmaceutical processes into continuous, streamlined production systems to on‐shore API manufacturing and eliminate drug shortages. This review will outline the current state‐of‐the‐art in the CM of APIs and will highlight the translation of chemistry and unit operations from batch processes to modular CM systems.

show abstract

Section: Blending and Mixingmentioning

confidence: 99%

“…For example, Waeytens et al . developed an extensive model to describe mixing behaviours inside twin‐screw feeders at different refill regimes [153] …”

Section: Unit Operationsmentioning

confidence: 99%

Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives

Hyer,

Gregory,

Kay

et al. 2024

Adv Synth Catal

View full text Add to dashboard Cite

show abstract

“…Particle scale simulations were carried out using the discrete element method (DEM) ( Hou et al, 2014 ; Bhalode and Ierapetritou, 2020 ). The mixing behaviors in the feeder were modeled by residence time distribution modeling ( Van Snick et al, 2019 ; Waeytens et al, 2022 ). Physical models with lumped parameters were developed based on the pressure exerted by the powder in the hopper and powder extrusion by the screw ( Wang et al, 2017b ; Bascone et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Feed factor profile prediction model for two-component mixed powder in the twin-screw feeder

Kobayashi,

Kim,

Nagato

et al. 2024

International Journal of Pharmaceutics: X

View full text Add to dashboard Cite

Predicting powder feedability: A workflow for assessing the risk of flow stagnation and defining the operating space for different powder-feeder combinations

Hörmann-Kincses

Beretta

Kruisz

et al. 2022

International Journal of Pharmaceutics

View full text Add to dashboard Cite

An extended 3-compartment model for describing step change experiments in pharmaceutical twin-screw feeders at different refill regimes

Cited by 4 publications

References 22 publications

Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives

Continuous Manufacturing of Active Pharmaceutical Ingredients: Current Trends and Perspectives

Feed factor profile prediction model for two-component mixed powder in the twin-screw feeder

Predicting powder feedability: A workflow for assessing the risk of flow stagnation and defining the operating space for different powder-feeder combinations

Contact Info

Product

Resources

About