An expression study of hormone receptors in spontaneously developed, carcinogen-induced and hormone-induced mammary tumors in female Noble rats

Characteristic Patterns of VEGF, Integrins, ER.ALPHA. and HER2 Immunoreactivity Suggest Two Tumor Cell Populations in DMBA-Induced Rat Mammary Tumor

“…This is consistent with the results from the estrogen receptor assay [5]. Recently, two immunohistochemical studies examined the ER expression in DMBA-induced mammary tumors that were induced by lower doses of DMBA in Sprague-Dawley or Noble rats [12,28]. These studies showed the weak to moderate nuclear immunostaining of ER, but did not show any characteristic patterns of ER immunostaining, as shown in this study.…”

Progesterone signalling in breast cancer: a neglected hormone coming into the limelight

“…The rat has been the mammary tumour model of choice for decades because tumours that mimic the histology of some human breast cancer subtypes can be reproducibly induced by chemical carcinogenesis, and these tumours show hormone dependence 91 and express hormone receptors 92 . Tumours that develop in the mouse mammary gland are mostly oestrogen receptor-α (ERα) negative.…”

Efeitos morfológicos, histológicos e moleculares dos moduladores seletivos dos receptores de estrogênios tamoxifeno e raloxifeno na prevenção primária de tumores mamários quimicamente induzidos em ratas

“…Muitos animais são utilizados em investigações experimentais para o estudo da carcinogênese mamária, mas, ainda hoje, os roedores são os animais preferidos pelo fácil manuseio, boa relação custo-benefício e pelas semelhanças estruturais e histológicas bem estabelecidas com a espécie humana (Russo et al 1982(Russo et al , 1990(Russo et al , 2005a(Russo et al , 2007Steele et al, 1994;Cardiff et al, 2002;Mehta, 2000;Cheung et al, 2003aCheung et al, , 2003bBlakely et al, 2006).…”

“…Vários autores (Huggins et al, 1959(Huggins et al, , 1961Dao e Sunderland, 1959;Dao, 1962Dao, , 1969Russo et al, 1982Russo et al, , 1990Russo et al, , 2005aBriand, 1983;Gould, 1995;Cheung et al, 2003aCheung et al, , 2003bHakkak et al, 2007) Assim, a maioria dos modelos animais experimentais descritos para câncer de mama utilizam os roedores.…”

“…Em ratas, os tumores induzidos quimicamente são hormônio-dependentes, segundo vários autores (Russo et al, 1990(Russo et al, , 1991(Russo et al, , 2005a(Russo et al, , 2005b(Russo et al, , 2005cCheung et al, 2003aCheung et al, , 2003b.…”