An Exploratory study to evaluate the efficacy of pimecrolimus cream 1% for the treatment of pityriasis alba

Abstract

Pimecrolimus cream 1% may represent an alternative for the treatment of pityriasis alba.

Double-Blind, Placebo-Controlled, Randomized Study Comparing 0.0003%Calcitriol with 0.1%Tacrolimus Ointments for the Treatment of Endemic Pityriasis Alba

“…Recently, immunosuppressors (i.e., tacrolimus, pimecrolimus) have shown an excellent response in atopic related PA [11, 12]. However, there are no clinical trials confirming its usefulness in endemic PA. Calcitriol (1,25-dihydroxyvitamin D3) is an endogenous hormonally-active derivative of vitamin D. Receptors for calcitriol in keratinocytes modulate differentiation and inflammation [13–17].…”

A Case of Extensive Pityriasis Alba

“…Extensive PA has been found to resolve with psoralen-UVA therapy 2 . In recent studies, pimecrolimus cream 1% and tacrolimus ointment 0.1% were proved as effective treatment 5 for typical PA 9,10 . To the best of our knowledge, our case is the first case of extensive PA in Korean literature.…”

Little white spots: an approach to hypopigmented macules

“…Although it has a variable course, it tends to worsen—or perhaps simply become more noticeable—during the summer months. Additionally, as one might expect, it is more prominent in patients with darker skin types 6. There is also a significant association with atopic dermatitis, rhinitis and asthma, and one series found that 85.5% of affected patients had a personal or family history of atopy 10.…”

“…In one study, the use of a moisturiser with sunscreen alone yielded significant improvement in nine weeks, suggesting that more dangerous and expensive treatments are probably not necessary for most cases 22. However, in the event that a patient or patient’s family is very concerned about his or her appearance, and the disease is refractory, low- to mid-potency topical corticosteroids used sparingly are the treatment of choice 6. Should this modality not be feasible, both tacrolimus and pimecrolimus have small studies that support their safety and efficacy, despite the relatively high price of these medications 6 22.…”

“…However, in the event that a patient or patient’s family is very concerned about his or her appearance, and the disease is refractory, low- to mid-potency topical corticosteroids used sparingly are the treatment of choice 6. Should this modality not be feasible, both tacrolimus and pimecrolimus have small studies that support their safety and efficacy, despite the relatively high price of these medications 6 22. Regardless of the `treatment, the prognosis is excellent as the majority of these cases resolve by puberty 10…”