This paper provides a disaster resilience-based approach. For the definition of the approach, a three-step method (definition of components, analysis of the resilience pillars and definitions of resilience-based actions) has been followed. To validate the approach, an application scenario for mitigating the COVID-19 pandemic is provided in the paper. The proposed approach contributes to stimulating the co-responsibility quadruple helix of actors in the implementation of actions for disaster management. Moreover, the approach is adaptable and flexible, as it can be used to manage different kinds of disasters, adjusting or changing itself to meet specific needs.