An Exploratory Study of Manganese Exposure to Welders

Chandra, Satya V.; Shukla, Girja S.; Srivastava, Roshni; Singh, Harwant; Gupta, V. P.

doi:10.3109/15563658108990264

Cited by 97 publications

(36 citation statements)

References 6 publications

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“…Our findings fit with others already noted in the scientific literature attesting to the release of manganese from welding activities causing neurologic damage, as well as a variety of other symptoms. This would include the work of Bowler [7], Chandra et al [16], Laohaudomchok et al [8], and Racette et al [9]. The finding in this study proves notable for the high rate of reported eye difficulties, even though most welders wear eye protection, albeit not very consistently.…”

Section: Short-term High Exposures (> 1 Mg/msupporting

confidence: 48%

Health effects of manganese exposures for welders in Qingdao City, China

Zhang

Wang

et al. 2016

Int J Occup Med Environ Health

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Objectives: To document if manganese from welding causes health effects including neurological symptoms associated with manganese exposure. Material and Methods: An anonymous questionnaire survey for a total of 505 welders at 3 welding facilities in Qingdao City, China was administered and analyzed. Results: Numerous symptoms were reported by the welders including difficulty with eyes for 43% of them, sore throat for 30% of them, and tremors were reported by over 18% of them. Tremors were associated with longer periods of work as a welder and correlated with the relative cleanliness at the 3 different facilities. Tremors did not correlate with smoking. Conclusions: Manganese-exposed welders reported a variety of symptoms related to work and showed neurological disturbances that correlated with amount of exposure. Int J Occup Med Environ Health 2017;30(2):241-247

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Section: Short-term High Exposures (> 1 Mg/msupporting

confidence: 48%

Health effects of manganese exposures for welders in Qingdao City, China

Zhang

Wang

et al. 2016

Int J Occup Med Environ Health

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“…Cases of manganese intoxication among welders who chronically inhale airborne manganese emitted during the welding process have been documented in literature (Chandra et al, 1981;Mergler et al, 1994;Roels et al, 1987;Sjogren et al, 1996;Smargiassi et al, 2000). The shielded metal arc weld, which is the most commonly used form of arc weld, can generate the fume containing manganese as high as 28.4% weight of hazardous air pollutant (US-EPA, 1994).…”

Section: Introductionmentioning

confidence: 99%

Alteration of Serum Concentrations of Manganese, Iron, Ferritin, and Transferrin Receptor Following Exposure to Welding Fumes Among Career Welders

Zhang

et al. 2005

NeuroToxicology

105

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This study was performed to determine airborne manganese levels during welding practice and to establish the relationship between long-term, low-level exposure to manganese and altered serum concentrations of manganese, iron, and proteins associated with iron metabolism in career welders. Ninety-seven welders (average age of 36 years) who have engaged in electric arc weld in a vehicle manufacturer were recruited as the exposed group. Welders worked 7-8 h per day with employment duration of 1-33 years. Control subjects consisted of 91 employees (average age of 35 years) in the same factory but not in the welding profession. Ambient manganese levels in welders' breathing zone were the highest inside the vehicle (1.5 ± 0.7 mg/m 3 ), and the lowest in the center of the workshop (0.2 ± 0.05 mg/m 3 ). Since the filter size was 0.8 μm, it is possible that these values may be likely an underestimation of the true manganese levels. Serum levels of manganese and iron in welders were about three-fold (p < 0.01) and 1.2-fold (p < 0.01), respectively, higher than those of controls. Serum concentrations of ferritin and transferrin were increased among welders, while serum transferrin receptor levels were significantly decreased in comparison to controls. Linear regression analyses revealed a lack of association between serum levels of manganese and iron. However, serum concentrations of iron and ferritin were positively associated with years of welder experience (p < 0.05). Moreover, serum transferrin receptor levels were inversely associated with serum manganese concentrations (p < 0.05). These findings suggest that exposure to welding fume among welders disturbs serum homeostasis of manganese, iron, and the proteins associated with iron metabolism. Serum manganese may serve as a reasonable biomarker for assessment of recent exposure to airborne manganese.

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“…However, cellular toxicity is an important drawback that challenges the applicability of Mn 2+ -enhanced MRI (MEMRI). It has been shown that Mn 2+ can be cytotoxic at concentrations used for neural tracing (Canals et al, 2008;Chandra et al, 1981;McMillan, 1999;Pal et al, 1999). Additional disadvantages of this technique are its high diffusion at the injection site, which challenge the specificity of the resulting projections, and its incompatibility with other visualization systems (Canals et al, 2008).…”

Section: Introductionmentioning

confidence: 99%