An exploratory research on antitumor effect of drug-eluting slow-releasing electrospinning membranes

Li, Li; Li, Feng; Zhao, Zhifeng; Xie, Rongli; Xu, Dan; Ding, Min; Zhang, Jun; Shen, Dongjie; Fei, Jian

doi:10.1016/j.heliyon.2023.e20295

Cited by 1 publication

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References 22 publications

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“…The results of the in vivo experiment also confirmed that the drug sustained-release nanomaterials had a better anti-tumor effect than intraperitoneal chemotherapy. Our findings align with previous research papers [ 25 , 26 ], however, the majority of scholars substantiate the efficacy of novel anti-tumor materials through in vivo and in vitro experiments, while neglecting to delve into the underlying molecular mechanisms [ 27 , 28 ].…”

Section: Discussionsupporting

confidence: 90%

Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment

Wang,

Yin,

Ren

et al. 2024

J Mater Sci: Mater Med

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The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors. Graphical abstract

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