An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects

Kitamura, Masahiro; Yamashita, Masaru; Miki, Koji; Ikegami, Kentaro; Takedachi, Masahide; Kashiwagi, Yoichiro; Nozaki, Tomoyoshi; Yamanaka, Katsuyuki; Masuda, Hiroki; Ishihara, Yoko; Murakami, Shinya

doi:10.1016/j.reth.2022.06.001

Cited by 14 publications

(30 citation statements)

References 25 publications

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“…More specifically more recent studies have shown positive results of the use of FGF-2 in severe periodontal defects in combination with a bone graft, even in the long term. 21,31 However, those studies could not be included in this systematic review due to the lack of a control group.…”

Section: Discussionmentioning

confidence: 99%

“…17 Animal studies have also proved its efficacy in periodontal regeneration thus several studies using FGF alone or in combination with various bone substitutes have been conducted in humans yielding promising results. [18][19][20][21] At present, however, it is unknown which combination of rhFGF-2 and various bone substitutes is desirable for obtaining predictable periodontal bone gain in the long term. Thus, the present systematic review aims to address the outcomes of periodontal regeneration using rhFGF alone or in combination with bone substitutes in terms of radiographic bone fill (RBF%) in a period over 6 months.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, rhFGF‐2 induces angiogenesis 17 . Animal studies have also proved its efficacy in periodontal regeneration thus several studies using FGF alone or in combination with various bone substitutes have been conducted in humans yielding promising results 18–21 . At present, however, it is unknown which combination of rhFGF‐2 and various bone substitutes is desirable for obtaining predictable periodontal bone gain in the long term.…”

Section: Introductionmentioning

confidence: 99%

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The role of rhFGF‐2 in periodontal defect bone fill: A systematic review of the literature

Pouliou¹,

Fragkioudakis

Doufexi

et al. 2023

J of Periodontal Research

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Background Growth factors have been used with success in periodontal regeneration, especially in intrabony defects. Among those, the recombined form of fibroblast growth factor‐2 (rhFGF‐2) has been also examined. Objective To address the outcomes of periodontal regeneration using rhFGF‐2 alone or in combination with bone substitutes primarily in terms of Radiographic Bone Fill (RBF%) and secondary Probing Pocket Depth (PPD), and Probing Attachment Levels (PAL). Material and Methods A search in MEDLINE and EMBASE using the Ovid interface was conducted from 2000 up to and including the 12th of November 2022. Starting from the initially identified 1289 articles, 34 studies were selected for further analysis. Following the full‐text screening, 7 of the 34 studies met the inclusion criteria and thus were included in the systematic review after assessing their quality according to the Newcastle‐Ottawa scale (NOS). Clinical and radiographic results (bone gain, pocket depth, and clinical attachment level) after the application of FGF‐2 alone or in combination with different carriers were studied in patients with intrabony defects of at least one wall and pocket depth greater than 4 mm. Results Primary outcomes: RBF% was higher in studies using a combination of rhFGF‐2 and bone substitutes (74.6 ± 20.0%) compared to others using the specific growth factor alone or negative controls (22.7 ± 20.7%). In terms of secondary outcomes, the analysis failed to show an additional benefit from the use of the rhFGF‐2 alone or in combination with bone substitutes. Conclusion rhFGF‐2 can improve RBF% in the treatment of periodontal defects, especially when it is used in combination with a bone substitute.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The role of rhFGF‐2 in periodontal defect bone fill: A systematic review of the literature

Pouliou¹,

Fragkioudakis

Doufexi

et al. 2023

J of Periodontal Research

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“…In learning about periodontal surgery, an inexperienced resident dentist must master the necessary conventional techniques through training in procedures such as GTR, application of EMD, and bone grafting. They are then required to master more advanced options such as the use of FGF-2, which necessitates learning about the characteristics [13]. The job of teaching staff in this respect is to impart such knowledge and the relevant skills, whether it be for use of FGF-2 or more conventional procedures.…”

Section: Discussionmentioning

confidence: 99%

Application of Medical Imaging and 3D Printing Technology in Teaching the Handling of Novel Medicine in Periodontal Surgery

Ogawa¹,

Kamio²,

Maeda³

et al. 2022

Cureus

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Recently, fibroblast growth factor-2 (FGF-2) agents for periodontal tissue regeneration have been increasingly applied to the treatment of periodontal disease. Our current challenge for resident dentists with little clinical experience is to enhance instruction in the handling of new medicine in addition to teaching conventional procedures in periodontal tissue regeneration. This report describes using case-specific, costeffective three-dimensional (3D) models for dentists' lectures and periodontal surgical training.As an educational and training aid, preoperative and postoperative cone-beam computed tomography images were superimposed to enable three-dimensional observation of postoperative bone regeneration. A three-dimensional anatomical model was fabricated based on these images. Dental laboratory materials were used to reproduce the periosteum and gum. The fabrication time per 3D model was about 2 hours and the cost per model was about $0.5. These models were used for lectures to resident dentists and periodontal surgery training, and their feedback was obtained. The resident's response to surgical training using these 3D models was generally positive.The use of FGF-2 represents a new direction in the treatment of periodontal disease. This being new, however, means that inexperienced periodontists require training in its application and how this will affect prognosis, as this will differ from that with more conventional techniques aimed at tissue regeneration. The low-cost 3D model presented in this report can be a valuable tool to help accomplish this in teaching inexperienced dentists, such as resident dentists.

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“…More specifically, the investigation of the effect of cytokines using recombinant basic fibroblast growth factor led to the development of a drug known as Regroth ® . Regroth was, for instance, clinically applied after being coupled with carbonated HAP granules (Kitamura et al, 2022). Studies have also been actively conducted on the utility of various cell sheets for periodontal tissue regeneration (Bousnaki, Beketova, & Kontonasaki, 2022;Onizuka & Iwata, 2019).…”

Section: Periodontal Tissue Regeneration In Dental Implant Therapymentioning

confidence: 99%

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

Saito

Onuma

Yamakoshi

2023

Genesis

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Summary The cementum is the outermost layer of hard tissue covering the dentin within the root portion of the teeth. It is the only hard tissue with a specialized structure and function that forms a part of both the teeth and periodontal tissue. As such, cementum is believed to be critical for periodontal tissue regeneration. In this review, we discuss the function and histological structure of the cementum to promote crystal engineering with a biochemical approach in cementum regenerative medicine. We review the microstructure of enamel and bone while discussing the mechanism underlying apatite crystal formation to infer the morphology of cementum apatite crystals and their complex structure with collagen fibers. Finally, the limitations of the current dental implant treatments in clinical practice are explored from the perspective of periodontal tissue regeneration. We anticipate the possibility of advancing periodontal tissue regenerative medicine via cementum regeneration using a combination of material science and biochemical methods.

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An exploratory clinical trial to evaluate the safety and efficacy of combination therapy of REGROTH® and Cytrans® granules for severe periodontitis with intrabony defects

Cited by 14 publications

References 25 publications

The role of rhFGF‐2 in periodontal defect bone fill: A systematic review of the literature

The role of rhFGF‐2 in periodontal defect bone fill: A systematic review of the literature

Application of Medical Imaging and 3D Printing Technology in Teaching the Handling of Novel Medicine in Periodontal Surgery

Cementum is key to periodontal tissue regeneration: A review on apatite microstructures for creation of novel cementum‐based dental implants

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