An exploratory association study of the influence of dysbindin and neuregulin polymorphisms on brain morphometry in patients with schizophrenia and healthy subjects from South India

Thirunavukkarasu, Priyadarshini; Vijayakumari, Anupa A.; John, John P.; Halahalli, Harsha N.; Paul, Pradip; Sen, Somdatta; Purushottam, Meera; Jain, Sanjeev

doi:10.1016/j.ajp.2014.04.002

Cited by 13 publications

(8 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have implicated NRG1 in patients with schizophrenia (Stefansson et al, 2002;Williams et al, 2003;Yang et al, 2003;Munafo et al, 2006;Pitcher et al, 2011). Recent report from Indian populations implicated NRG1 with schizophrenia (Kukshal et al, 2013;Thirunavukkarasu et al, 2014). Studied variant (rs17603876) is in LD with rs12155594, associated with transition to psychosis (Bousman et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

Jajodia

Kaur

Kumari

et al. 2015

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

Jajodia

Kaur

Kumari

et al. 2015

Schizophrenia Research

Self Cite

View full text Add to dashboard Cite

“…Indeed, a more logical strategy would be to examine the sources of the variability of morphometric findings across samples, most important of which are the molecular genetic factors. These factors might include genetic and epigenetic factors, including the individual and additive effects of the multiple genes responsible for schizophrenia diathesis on brain development, as recently reported from our laboratory [48, 49]. …”

Section: Discussionmentioning

confidence: 95%

A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

John

Lukose

Bagepally

et al. 2015

J Negat Results BioMed

Self Cite

View full text Add to dashboard Cite

BackgroundBrain morphometric abnormalities in schizophrenia have been extensively reported in the literature. Whole-brain volumetric reductions are almost universally reported by most studies irrespective of the characteristics of the samples studied (e.g., chronic/recent-onset; medicated/neuroleptic-naïve etc.). However, the same cannot be said of the reported regional morphometric abnormalities in schizophrenia. While certain regional morphometric abnormalities are more frequently reported than others, there are no such abnormalities that are universally reported across studies. Variability of socio-demographic and clinical characteristics across study samples as well as technical and methodological issues related to acquisition and analyses of brain structural images may contribute to inconsistency of brain morphometric findings in schizophrenia. The objective of the present study therefore was to systematically examine brain morphometry in patients with recent-onset schizophrenia to find out if there are significant whole-brain or regional volumetric differences detectable at the appropriate significance threshold, after attempting to control for various confounding factors that could impact brain volumes.MethodsStructural magnetic resonance images of 90 subjects (schizophrenia = 45; healthy subjects = 45) were acquired using a 3 Tesla magnet. Morphometric analyses were carried out following standard analyses pipelines of three most commonly used strategies, viz., whole-brain voxel-based morphometry, whole-brain surface-based morphometry, and between-group comparisons of regional volumes generated by automated segmentation and parcellation.ResultsIn our sample of patients having recent-onset schizophrenia with limited neuroleptic exposure, there were no significant whole brain or regional brain morphometric abnormalities noted at the appropriate statistical significance thresholds with or without including age, gender and intracranial volume or total brain volume in the statistical analyses.ConclusionsIn the background of the conflicting findings in the literature, our findings indicate that brain morphometric abnormalities may not be directly related to the schizophrenia phenotype. Analysis of the reasons for the inconsistent results across studies as well as consideration of alternate sources of variability of brain morphology in schizophrenia such as epistatic and epigenetic mechanisms could perhaps advance our understanding of structural brain alterations in schizophrenia.Electronic supplementary materialThe online version of this article (doi:10.1186/s12952-015-0030-z) contains supplementary material, which is available to authorized users.

show abstract

“…251 A major issue in brain morphometric research in schizophrenia is the poor replicability of findings across studies. 7,252,253 Confounding factors such as age, age of onset, 254 illness chronicity, 255 medication, 256 substance use, 257,258 symptom heterogeneity 259 and unequal gender distribution 260,261 or handedness of study samples 261,262 could contribute to the inconsistent findings, especially when they are not controlled for in the analyses. Other issues related to MRI acquisition (strength of the magnet, acquisition protocols, etc.)…”

mentioning

confidence: 92%

“…Definitive conclusions regarding relationship between brain structural alterations and gene polymorphisms should only be made when the results survive the appropriate correction for multiple comparisons. 7,253 Uncorrected results should only be considered as trends, which should guide future studies in estimating an appropriate sample size that could generate reliable results that survive statistical correction.…”

mentioning

confidence: 98%

A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia

John

Thirunavukkarasu

Halahalli

et al. 2015

Neurology, Psychiatry and Brain Research

Self Cite

View full text Add to dashboard Cite

An exploratory association study of the influence of dysbindin and neuregulin polymorphisms on brain morphometry in patients with schizophrenia and healthy subjects from South India

Cited by 13 publications

References 37 publications

Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

Evidence for schizophrenia susceptibility alleles in the Indian population: An association of neurodevelopmental genes in case–control and familial samples

A systematic examination of brain volumetric abnormalities in recent-onset schizophrenia using voxel-based, surface-based and region-of-interest-based morphometric analyses

A systematic review of the effect of genes mediating neurodevelopment and neurotransmission on brain morphology: Focus on schizophrenia

Contact Info

Product

Resources

About