An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock

Bronner, Madelon B.; Knoester, Hendrika; Sol, Jeanine J.; Bos, Albert P.; Heymans, H. S. A.; Grootenhuis, Martha A.

doi:10.1097/pcc.0b013e3181ae5c1a

Cited by 62 publications

(59 citation statements)

References 45 publications

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“…One other study reported worse cognitive functioning in children who survived septic shock, but in this study only self-reports were used (19). Elison et al (20) found a specific deficit for pattern recognition memory in their study with three MSS children aged 6 to 12 yrs old, 3 to 7 months after discharge.…”

Section: Cognitive Functioningmentioning

confidence: 95%

Survivors of septic shock caused by Neisseria meningitidis in childhood: Psychosocial outcomes in young adulthood

Vermunt

Buysse

Joosten

et al. 2011

Pediatric Critical Care Medicine

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Section: Cognitive Functioningmentioning

confidence: 95%

Survivors of septic shock caused by Neisseria meningitidis in childhood: Psychosocial outcomes in young adulthood

Vermunt

Buysse

Joosten

et al. 2011

Pediatric Critical Care Medicine

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“…Discrepancies may be related to differences in inclusion criteria; length of follow-up; and use or not of healthy controls. Cognitive sequelae have been identified in sub-groups of acutely ill children, including meningitis (16)(17)(18)(19), sepsis or septic shock (7,20,21), and meningococcal disease (22,23).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychologic Function Three to Six Months Following Admission to the PICU With Meningoencephalitis, Sepsis, and Other Disorders

Als

Nadel

Cooper

et al. 2013

Critical Care Medicine

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Objective: To assess short-term neuropsychological function and academic performance in school children following admission to intensive care and to explore the role of critical neurological and systemic infection.Design: A prospective observational case-control study.Setting: Two Paediatric Intensive Care Units (PICUs).Subjects: A consecutive sample of 88 children aged 5-16 years (Mdn age = 10.00, IQR = 6.00-13.00) admitted to PICU between 2007 and 2010 with meningo-encephalitis, septic illness, or other critical illnesses were assessed three to six months following discharge and performance compared with 100 healthy controls. Patients were without prior neurological or neuro-developmental disorder.Interventions: None.Measurements and Main Results: Data encompassing demographic and critical illness details were obtained and children were assessed using tests of intellectual function, memory, and attention. Questionnaires addressing academic performance were returned by teachers. After adjusting for co-variates, the PICU admitted children significantly underperformed on neuropsychological measures in comparison to the healthy controls (ps<.02). Teachers deemed more PICU children than controls as performing educationally worse and having problems with school work (ps=.001), as well as performing below average on aspects of executive function and attention (ps<.04). Analysis of the effect of illness type on outcome revealed that aspects of 3 neuropsychological function, such as memory function, and teacher-rated academic performance were most reduced in children with meningo-encephalitis and septic illness. In the PICU group, multivariable linear regression revealed that worse performance on a composite score of neuropsychological impairment was more prevalent when children were younger, from a lower social class, and had experienced seizures during their admission (ps<.02).Conclusions: Admission to PICU is followed by deficits in neuropsychological performance and educational difficulties, with more severe difficulties noted following meningo-encephalitis and septic illness. These results highlight the importance of future studies on cognition and educational outcome incorporating type of illness as a moderating factor.

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“…Severe sepsis and septic shock are major healthcare problems that affect millions of people around the world each year, killing one in four compromised people (Dellinger et al 2013b). Besides this elevated mortality, several studies have demonstrated that sepsis survivors present long-term impairment in cognition, including changes in memory, attention, concentration and/or global cognitive decline (Bronner et al 2009;Hopkins et al 2004;Iwashyna et al 2010;Jackson et al 2011;Rothenhausler et al 2001).…”

Section: Introductionmentioning

confidence: 99%

TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF

et al. 2014

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The involvement of TNF-α type 1 receptor (TNFR1) in memory deficits induced by sepsis was explored by using TNFR1 knockout (KO) mice. We reported that wild type (WT) mice presented memory deficits in the novel object recognition test 10 days after sepsis induced by cecum ligation and perforation (CLP). These deficits were not observed in TNFR1 KO mice. The involvement of serum and brain cytokines TNF-α, IL-1β, IL-6, IFN-γ and IL-10 was then investigated. TNFR1 KO mice had higher serum levels of TNF-α and IL-1β, and brain levels of TNF-α than WT mice. After CLP, the brain levels of TNF-α, IL-1β, IL-6 and IFN-γ increased in both WT and KO mice. Our next step was to determine the expression of inflammatory cytokines, BDNF and TrKb in the hippocampus. The absence of TNFR1 in mice subjected to polymicrobial sepsis resulted in higher BDNF expression in the hippocampus. In conclusion, after CLP, memory is preserved in the absence of TNFR1. This finding was associated with increased BDNF expression in the hippocampus.

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An explorative study on quality of life and psychological and cognitive function in pediatric survivors of septic shock

Cited by 62 publications

References 45 publications

Survivors of septic shock caused by Neisseria meningitidis in childhood: Psychosocial outcomes in young adulthood

Survivors of septic shock caused by Neisseria meningitidis in childhood: Psychosocial outcomes in young adulthood

Neuropsychologic Function Three to Six Months Following Admission to the PICU With Meningoencephalitis, Sepsis, and Other Disorders

TNFR1 absence protects against memory deficit induced by sepsis possibly through over-expression of hippocampal BDNF

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