An Explicit Review on Quantitative Estimation of Candesartan Cilexetil Employing Various Analytical Techniques

Shantanu, B; yopadhyay,; Bhuria, Lohit; Lal, Devi

doi:10.4172/2153-2435.1000254

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Candesartan cilexetil (CC) is a selective, reversible, competitive angiotensin II receptor-1 antagonist, and it's used for the management of hypertension, heart failure, and myocardial infarction. It is also used in patients with impaired left ventricular systolic function, either when ACE inhibitors are not tolerated, or in addition to ACE inhibitors (14,15) .…”

Section: Introductionmentioning

confidence: 99%

Novel Combination for Self-Nanoemulsifying Drug Delivery System of Candesartan Cilexetil

Mekhilef¹,

Hussein²

2018

IJPS

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Solubility problem of many of effective pharmaceutical molecules are still one of the major obstacle in theformulation of such molecules. Candesartan cilexetil (CC) is angiotensin II receptor antagonist with very low water solubility and this result in low and variable bioavailability. Self- emulsifying drug delivery system (SEDDS) showed promising result in overcoming solubility problem of many drug molecules. CC was prepared as SEDDS by using novel combination of two surfactants (tween 80 and cremophore EL) and tetraglycol as cosurfactant, in addition to the use of triacetin as oil. Different tests were performed in order to confirm the stability of the final product which includes thermodynamic study, determination of self-emulsification time, particle size and zeta potential measurement, and in-vitro drug release. The results showed that the particle size of the best formula was 13.3 nm and zeta potential of -37.45 mV with approximately 100% release after 45 minutes .These results suggest that the preparation of CC. as SEDDS with the use of the above combination of surfactant and cosurfactant is a promising maneuver for oral delivery of CC. in order to improve its bioavailability.

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Section: Introductionmentioning

confidence: 99%

Novel Combination for Self-Nanoemulsifying Drug Delivery System of Candesartan Cilexetil

Mekhilef¹,

Hussein²

2018

IJPS

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“…It contains two acidic functional groups: a carboxyl and tetrazole moieties and its pKa values were calculated to be 4.22 in its unionized form and 4.24 in its ionized form (Beale et al 2010;Bandyopadhyay et al 2013). The CC is a racemic mixture containing one chiral center at the ester group.…”

Section: Introductionmentioning

confidence: 99%

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

Ali

Hussein

2017

AAPS Open

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Nanoemulsion is considered to be a new and exciting field of research that seeks to exploit the attractive properties of components to improve oral delivery of drugs like candesartan cilexetil used in the management of chronic diseases. Candesartan cilexetil is a lipophilic acidic drug with a half-life of about (5-10) hour and absolute bioavailability of (14-40%). For this reason, the study target was to formulate and characterize candesartan cilexetil nanoemulsions that could improve solubility, dissolution and stability of the lipophilic drug candesartan cilexetil. The solubility of candesartan cilexetil was checked in various vehicles in order to choose the best solubilizing components for building up an efficient nanoemulsion based on regulating hydrophilic/lipophilic balance (HLB) value above 10, and then pseudo-ternary phase diagram was used as a useful tool to evaluate the nanoemulsion domain. The nanoemulsion formulations were prepared using various concentrations of cinnamon oil, tween 80 with poloxamer mixture and transcutol HP as oil, surfactant mixture and co-surfactant respectively by aqueous titration method at surfactant/co-surfactant ratios of 3:1 and 4:1 and varying the type of poloxamer in each ratio. The prepared nanoemulsions were tested for nanodispersion stability studies, droplet size distribution, polydispersity index, zeta potential, viscosity, filter paper spreadability, dye miscibility, electroconductivity, pH, percent transmittance, surface tension, refractive index, morphology and drug dissolution. It was found that release rate and extent for all prepared nanoformulations were significantly higher (p < 0.05) than marketed tablet formulation as well as plain drug powder. The results demonstrated that, the potential use of this system is a perfect technique for improving solubility and dissolution of candesartan cilexetil.

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“…The melting point of candesartan cilexetil powder was measured by putting a small amount of candesartan cilexetil powdered drug into a capillary glass tube that sealed from one side and opened from another side, then the tube placed in digital melting point instrument and temperature of melting was recorded, when complete melting of powdered drug occurs [6].…”

Section: Methodsmentioning

confidence: 99%

A a Comparative Study of Quality Control Testing on Candesartan Cilexetil Conventional Tablets in Iraq

Hamrah¹,

Al-Shaibani²,

Al-Edresi³

et al. 2020

Int J App Pharm

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Objective: The present study was performed to compare the quality of conventional tablets loaded with candesartan cilexetil. The selected candesartan cilexetil tablets were commercialized in the Iraq market and produced by different companies. Methods: Different batches of candesartan cilexetil oral tablets (the concentration of candesartan was 8 mg) were subjected to quality control tests. Tests included weight variation, friability, hardness, drug content, disintegration time and in vitro release study. The protocols of these tests were performed according to USP pharmacopeia. Results: The results, in this study, revealed that all the used batches of candesartan cilexetil oral tablets complied with the specification of USP pharmacopeia for weight uniformity, friability value (% loss) was<1. Hardness results of the tablets were 4.9-6.6 Kg/cm2, which was within the required limits (i.e. 4-8 Kg/cm2). Disintegration time was<15 min in both Simulated Gastric Fluid (SGF) and Simulated Intestinal Fluid (SIF). The percentage of drug content in all marketed tablets was found between 96.2 % and 99.8 %, reflecting compliance with the pharmacopeia limits (i.e. 85-115 %). An in vitro release study indicated that the release of all marketed tablets exceeds 80 % within 15 min. Conclusion: All the studied tablets, loaded with candesartan cilexetil, were produced within the standard criteria of tablet production. The quality control analysis of the selected tablets, in this study, revealed satisfactory pharmaceutical properties (including safety and effectiveness) that comply within the limits of USP pharmacopeia.

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An Explicit Review on Quantitative Estimation of Candesartan Cilexetil Employing Various Analytical Techniques

Abstract: Pha rm a c e u tic a An a ly t ic a A cta

Cited by 8 publications

References 44 publications

Novel Combination for Self-Nanoemulsifying Drug Delivery System of Candesartan Cilexetil

Novel Combination for Self-Nanoemulsifying Drug Delivery System of Candesartan Cilexetil

Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

A a Comparative Study of Quality Control Testing on Candesartan Cilexetil Conventional Tablets in Iraq

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