“…Although most studies have reported that BVA is effective for LBP, six studies reported side effects including fever [36], itching [51,52,59,82], local redness [59], edema [59], skin hypersensitivity [73], mild chilling [82], and local rash [82]. BV contains active substances such as peptides, enzymes, and amines, which can exert anti-inflammatory, anti-nociceptive, and anticancer effects, but can also induce neurotoxic symptoms (e.g., redness, swelling, dizziness, nausea, and vomiting) or severe symptoms, such as anaphylaxis [87,88].…”