An Experimental Study on the Effect of Safflower Yellow on Tendon Injury-Repair in Chickens

Liu, Bingbing; Luo, Cheng; Ouyang, Liang; Mu, Shuhua; Zhu, Yaxi; Li, Keyi; Zhan, Mali; Liu, Zongwei; Yu, Jiaguo; Lei, Wanlong

doi:10.1016/j.jss.2011.03.079

Cited by 13 publications

(5 citation statements)

References 21 publications

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“…Bromelain is an enzyme extracted from the stem of the pineapple plant. Liu et al () reported that the local application of safflower yellow improved tendon healing by up‐regulating expression of bFGF and collagen type I. Previous data from our group also showed the effectiveness of topical application of Aloe vera ointment and Arrabidaea chica extract during tendon healing, with higher MMP‐2 activity and higher collagen organization compared with control groups (Aro et al, ).…”

Section: Discussionsupporting

confidence: 59%

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Aro

Perez

Vieira

et al. 2014

The Anatomical Record

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In recent years, the scientific community has undertaken research on plant extracts, searching for compounds with pharmacological activities that can be used in diverse fields of medicine. Calendula officinalis L. is known to have antioxidant, anti-inflammatory, antibacterial, and wound healing properties when used to treat skin burns. Therefore, the purpose of this study was to analyze the effects of C. officinalis on the initial phase of Achilles tendon healing. Wistar rats were separated in three groups: Calendula (Cal)-rats with a transected tendon were treated with topical applications of C. officinalis cream and then euthanized 7 days after injury; Control (C)-rats were treated with only vehicle after transection; and Normal (N)-rats without tenotomy. Higher concentrations of hydroxyproline (an indicator of total collagen) and non-collagenous proteins were observed in the Cal group in relation to the C group. Zymography showed no difference in the amount of the isoforms of metalloproteinase-2 and of metalloproteinase-9, between C and Cal groups. Polarization microscopy images analysis showed that the Cal group presented a slightly higher birefringence compared with the C group. In sections of tendons stained with toluidine blue, the transected groups presented higher metachromasy as compared with the N group. Immunocytochemistry analysis for chondroitin-6-sulfate showed no difference between the C and Cal groups. In conclusion, the topical application of C. officinalis after tendon transection increases the concentrations of collagen and non-collagenous proteins, as well as the collagen organization in the initial phase of healing. Anat Rec, 298:428-435, 2015. V C 2014 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 59%

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Aro

Perez

Vieira

et al. 2014

The Anatomical Record

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“…Given the anti‐fibrotic effect, traditional Chinese drugs have achieved positive effects in preventing post‐operative fibrosis, including salvianolic acid B, angelica sinensis, safflower yellow and daidzein . Non‐steroidal anti‐inflammatory drug (NSAIDs), including ketoprofen, aceclofenac, indomethacin and ibuprofen, could also modify local inflammation response and prevent post‐operative fibrosis.…”

Section: Current Therapies For Post‐operative Skeletal Fibrosismentioning

confidence: 99%

Prospective application of stem cells to prevent post‐operative skeletal fibrosis

Song²,

Yan

et al. 2019

Journal Orthopaedic Research

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Post‐operative skeletal fibrosis is considered one of the major complications causing dysfunction of the skeletal system and compromising the outcomes of clinical treatment. Limited success has been achieved using current therapies; more effective therapies to reduce post‐operative skeletal fibrosis are needed. Stem cells possess the ability to repair and regenerate damaged tissue. Numerous studies show that stem cells serve as a promising therapeutic approach for fibrotic diseases in tissues other than the skeletal system by inhibiting the inflammatory response and secreting favorable cytokines through activating specific signaling pathways, acting as so‐called medicinal signaling cells. In this review, current therapies are summarized for post‐operative skeletal fibrosis. Given that stem cells are used as a promising therapeutic approach for fibrotic diseases, little effort has been undertaken to use stem cells to prevent post‐operative skeletal fibrosis. This review aims at providing useful information for the potential application of stem cells in preventing post‐operative skeletal fibrosis in the near future. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1236–1245, 2019.

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“…Tendon repairs often fail as a result of a sudden motion (Deslandes et al, 2008). However, most studies investigating tendon repair apply relatively slow loading rates , often in the range of 0.33 mm/s (Liu et al, 2011; Momose et al, 2001). in contrast, the flexor pollicis longus velocity in healthy individuals ranges between 80 mm/s and 180 mm/s (Cigali et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Does loading velocity affect failure strength after tendon repair?

Parimi

Zhao

Thoreson

et al. 2012

Journal of Biomechanics

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Tensile testing of repaired tendons has been used to assess the efficacy of repair techniques. However, individuals flex and extend fingers at rates higher than those typically used for testing. This study characterized the effect of loading rate on the failure strength of repaired canine flexor tendons. Thirty six canine flexor digitorum profundus tendons were lacerated, repaired, and tested at three displacement rates: 0.33 mm/s; 84 mm/s; and 590 mm/s. Peak force and stiffness of the repairs were evaluated. Peak force was significantly greater (p<0.05) for tendons distracted at 590 mm/s than at 0.33 mm/s. Crosshead stiffness was significantly greater for tendons distracted at 590 mm/s than at either 84 mm/s or 0.33 mm/s. The predominant failure mode was core suture knot untying. Distracting tendons at slow loading rates provides a conservative assessment of tendon repair strength. Additionally, an estimate of the failure load of this repair for different clinical events has been identified.

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An Experimental Study on the Effect of Safflower Yellow on Tendon Injury-Repair in Chickens

Cited by 13 publications

References 21 publications

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Effect of Calendula Officinalis Cream on Achilles Tendon Healing

Prospective application of stem cells to prevent post‐operative skeletal fibrosis

Does loading velocity affect failure strength after tendon repair?

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