An experimental study of the mouse skin behaviour: Damage and inelastic aspects

Muñoz, Mario; Bea, José Antonio; Rodrı́guez, José F.; Ochoa, Ignacio; Grasa, J.; Palomar, Amaya Pérez del; Zaragoza, Pilar; Osta, Rosario; Doblaré, M.

doi:10.1016/j.jbiomech.2007.07.013

Cited by 87 publications

(68 citation statements)

References 22 publications

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“…The remarkable residual deformations demonstrated by the dermis samples in the present study are in line with recent observations on skin specimens including all layers [Muñoz et al 2008].…”

Section: Discussionsupporting

confidence: 93%

“…Keywords: dermis, anisotropy, constitutive modeling, preconditioning, soft tissues, mechanical testing, cyclic loading. Delalleau et al 2006], and mice [Del Prete et al 2004;Muñoz et al 2008]. Since physiologically relevant loading states are of a biaxial nature, Lanir and Fung [1974] investigated the biaxial viscoelastic stress response of rectangular rabbit skin samples, the width of which was fixed during elongation.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, Muñoz et al [2008] have presented an interesting study on the inelastic behaviour of murine skin subject to uniaxial cyclic loading, where the load was successively increased in each step. Besides remarkable residual strains growing with the achieved maximal stretch, they found softening characteristics which clearly resemble the Mullins effect [Mullins 1947] in rubber-like materials.…”

Section: Introductionmentioning

confidence: 99%

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Porcine dermis in uniaxial cyclic loading: Sample preparation, experimental results and modeling

Ehret¹,

Hollenstein²,

Mazza³

et al. 2011

J. Mech. Mater. Struct.

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We present a straightforward technique to prepare thin samples of planar or bulky soft tissue with very accurate geometry. The experimental procedure includes the preparation of thin slices of tissue by means of a surgical dermatome and specimen extraction by die cutters. We illustrate this method in application to porcine dermal tissue. The prepared specimens were subjected to uniaxial cyclic tension along and across the lines of cleavage with increasing upper stretch limits. Besides a distinct anisotropic and nonlinear behavior, cyclic loading caused considerable preconditioning effects including softening and substantial residual deformations. This observed behavior is well represented by a recently proposed constitutive model accounting for the elastic and dissipative behavior of soft tissues.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porcine dermis in uniaxial cyclic loading: Sample preparation, experimental results and modeling

Ehret¹,

Hollenstein²,

Mazza³

et al. 2011

J. Mech. Mater. Struct.

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show abstract

“…However, if the system is sheared to a maximum strain > γ 0 , the stress-strain relation exhibits no memory of the previously applied strain. This type of softening behavior, referred to as the Mullins effect, is observed in pure and filled gums and thermoplastic elastomers 5 , as well as polymer gels 6 , living tissues 7,8 and biopolymer networks 9 . The microscopic origin of the Mullins effect remains unclear 5 in spite of the variety of existing models 10 .…”

mentioning

confidence: 97%

Cyclic hardening in bundled actin networks

et al. 2010

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nonlinear deformations can irreversibly alter the mechanical properties of materials. most soft materials, such as rubber and living tissues, display pronounced softening when cyclically deformed. Here we show that, in contrast, reconstituted networks of crosslinked, bundled actin filaments harden when subject to cyclical shear. As a consequence, they exhibit a mechanomemory where a significant stress barrier is generated at the maximum of the cyclic shear strain. This unique response is crucially determined by the network architecture: at lower crosslinker concentrations networks do not harden, but soften showing the classic mullins effect known from rubber-like materials. By simultaneously performing macrorheology and confocal microscopy, we show that cyclic shearing results in structural reorganization of the network constituents such that the maximum applied strain is encoded into the network architecture.

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“…More specifically, in our model [70], we connected the macroscopic stretches to the chains elongations (the Cauchy-Born rule) based on the affine hypothesis [74] and an 8-chain network cell [13]. The predictability of the resulting model is described in figure 4d,e for the cyclic loading of mouse skin reproduced by Muñoz et al [71] and the shear behaviour of pig (passive) myocardium tissues reproduced by Dokos et al [72], respectively. The numerical extension of the model to the 3-chain approach has been exemplified in figure 4f, where we reproduce the experimental behaviour of Senegalensis Nephila spider silks from Vehof et al [73].…”

Section: Multi-scale and Microstructure-inspired Continuum Modelsmentioning

confidence: 99%

Multi-scale modelling of rubber-like materials and soft tissues: an appraisal

Puglisi

Saccomandi

2016

Proc. R. Soc. A.

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We survey, in a partial way, multi-scale approaches for the modelling of rubber-like and soft tissues and compare them with classical macroscopic phenomenological models. Our aim is to show how it is possible to obtain practical mathematical models for the mechanical behaviour of these materials incorporating mesoscopic (network scale) information. Multi-scale approaches are crucial for the theoretical comprehension and prediction of the complex mechanical response of these materials. Moreover, such models are fundamental in the perspective of the design, through manipulation at the micro-and nano-scales, of new polymeric and bioinspired materials with exceptional macroscopic properties.

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An experimental study of the mouse skin behaviour: Damage and inelastic aspects

Cited by 87 publications

References 22 publications

Porcine dermis in uniaxial cyclic loading: Sample preparation, experimental results and modeling

Porcine dermis in uniaxial cyclic loading: Sample preparation, experimental results and modeling

Cyclic hardening in bundled actin networks

Multi-scale modelling of rubber-like materials and soft tissues: an appraisal

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