An experimental study of the aerodynamic dispersion of loose aggregates in an accelerating flow

Silin, N.; Tarrio, Juan; Guozden, T. M.

doi:10.1016/j.powtec.2017.05.043

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Particle dispersion is also associated with impaction, shear stress, and turbulent flow [ 39 ]. To identify the particle dispersion dynamics, several studies have been carried out using approaches such as computational fluid dynamics (CFD) [ 40 , 41 ] and PIV system [ 42 , 43 ]. In this study, PIV was used to provide experimental observation of the particle dispersion process.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

et al. 2020

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The purpose of this study was to prepare spray dried bosentan microparticles for dry powder inhaler and to characterize its physicochemical and aerodynamic properties. The microparticles were prepared from ethanol/water solutions containing bosentan using spray dryer. Three types of formulations (SD60, SD80, and SD100) depending on the various ethanol concentrations (60%, 80%, and 100%, respectively) were used. Bosentan microparticle formulations were characterized by scanning electron microscopy, powder X-ray diffraction, laser diffraction particle sizing, differential scanning calorimetry, Fourier-transform infrared spectroscopy, dissolution test, and in vitro aerodynamic performance using Andersen cascade impactor™ (ACI) system. In addition, particle image velocimetry (PIV) system was used for directly confirming the actual movement of the aerosolized particles. Bosentan microparticles resulted in formulations with various shapes, surface morphology, and particle size distributions. SD100 was a smooth surface with spherical morphology, SD80 was a rough surfaced with spherical morphology and SD60 was a rough surfaced with corrugated morphology. SD100, SD80, and SD60 showed significantly high drug release up to 1 h compared with raw bosentan. The aerodynamic size of SD80 and SD60 was 1.27 µm and SD100 was 6.95 µm. The microparticles with smaller particle size and a rough surface aerosolized better (%FPF: 63.07 ± 2.39 and 68.27 ± 8.99 for SD60 and SD80, respectively) than larger particle size and smooth surface microparticle (%FPF: 22.64 ± 11.50 for SD100).

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Section: Resultsmentioning

confidence: 99%

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

et al. 2020

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“…The camera resolution is 1280 × 1024 pixel. Illumination pulses were produced by a Nichia NUBM44 laser diode module driven by the custom made electronic circuit described by Silin et al (2017). The laser diode module includes a collimating glass lens assembly with adjustable focus in order to produce a collimated laser beam.…”

Section: Particle Image Velocimetrymentioning

confidence: 99%

Experimental assessment on the performance of hot wire anemometry in and around a permeable medium by comparison with Particle Image Velocimetry

Silin

Cuscueta

Clausse

2021

Flow Measurement and Instrumentation

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Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies

Islam,

Suwandecha,

Srichana

2024

DARU J Pharm Sci

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An experimental study of the aerodynamic dispersion of loose aggregates in an accelerating flow

Cited by 5 publications

References 30 publications

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

The Effect of Particle Size and Surface Roughness of Spray-Dried Bosentan Microparticles on Aerodynamic Performance for Dry Powder Inhalation

Experimental assessment on the performance of hot wire anemometry in and around a permeable medium by comparison with Particle Image Velocimetry

Dry powder inhaler design and particle technology in enhancing Pulmonary drug deposition: challenges and future strategies

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