An experimental study of the effect of the thyroid on the motility of the gastro-lntestinal tract

Morrison, Samuel; Feldman, Maurice

doi:10.1007/bf02997035

Cited by 8 publications

(2 citation statements)

References 5 publications

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“…The same phenomenon was also observed experimentally (19). The opposite, namely, abnormally sluggish intestinal peristalsis, is characteristic of myxedema, in which there is also a markedly diminished fecal output of calcium.…”

Section: Commentssupporting

confidence: 74%

Calcium Exchange of the Intestine in Experimental Hyperthyroidism 12

Althausen¹,

Kerr²,

Stockholm³

1939

J. Clin. Invest.

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Section: Commentssupporting

confidence: 74%

Calcium Exchange of the Intestine in Experimental Hyperthyroidism 12

Althausen¹,

Kerr²,

Stockholm³

1939

J. Clin. Invest.

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“…Regardless of the mechanism by which thyroid hormones influence the functions of the esophagus, it seems that thyroid disorders influence the smooth muscle of the distal esophagus and reversibility of this effect suggests a physiologic dysregulation (9). Although the autonomic dysfunction is a possible candidate to explain motility dysfunction in hyperthyroidism, induced hyperthyroidism increased the gastrointestinal motility regardless of whether the vagal nerve was intact in an experimental study (14). In the previous studies, motility disorders were evaluated generally using scintigraphic and electrogastrographic methods.…”

Section: Discussionmentioning

confidence: 94%

Does Graves’ Disease Affect Esophageal Motility?

et al. 2018

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Context. The gastrointestinal tract is one of the most affected systems in hyperthyroidism. Although thyrotoxicosis is thought to be associated with gastrointestinal dysmotility, there are limited studies focused on motility disorders in hyperthyroidism. Objectives. We aimed to investigate the manometric measurements to determine if esophageal motility is affected in Graves' disease. Materials and Methods. Thirty patients with Graves' disease (18 female and 12 male) and 30, age and sex matched, healthy controls (22 female and 8 male) were recruited to the study between 2015 and 2016. Esophageal manometry was performed using MMS (Medical Measurement Systems bv. The Netherlands) Solar GI-Air Charged Intelligent Gastrointestinal Conventional Manometry. Results. The mean lower esophageal sphincter pressure (LESP) was 16.9 ± 5.3 mmHg in hyperthyroid patients and 20.1 ± 8.8 mmHg in the control group and there was no significant difference (p>0.05). It was observed that the duration of contraction was 3.9 ± 0.7 s in healthy subjects and, significantly shorter 3.2 ± 0.5 s in hyperthyroid patients (p<0.001). Duration of contraction was negatively correlated with TSH receptor Ab titer in patients (p=0.006, r=-0.48). Also, it was observed that the duration of relaxation was negatively correlated with fT4 levels in the patient group (p<0.05, r=-0.46). Conclusion. In this study, we observed that esophageal motility can be affected via shortened duration of contraction in Graves' disease. The gastrointestinal symptoms due to possible motility dysfunctions should be considered in the evaluation of hyperthyroid patients.

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An experimental study of the effect of the pituitary on the motility of the gastro-intestinal tract

Morrison

Feldman

1940

Am. J. Dig. Dis.

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An experimental study of the effect of the thyroid on the motility of the gastro-lntestinal tract

Cited by 8 publications

References 5 publications

Calcium Exchange of the Intestine in Experimental Hyperthyroidism 12

Calcium Exchange of the Intestine in Experimental Hyperthyroidism 12

Does Graves’ Disease Affect Esophageal Motility?

An experimental study of the effect of the pituitary on the motility of the gastro-intestinal tract

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