An experimental study of the recanalization of arterial and venous thrombi

Evaluation of thrombolysis in a porcine model of chronic deep venous thrombosis: An endovascular model

“…24 The increased plasmin content and tissue plasminogen activators may in part explain why venous thrombosis remained partially recanalized. 25 The efficacy of thrombolytic therapy was assessed with venography and IVUS in our study. Although venography provided useful information regarding the degree of recannalization after thrombolysis, it is less accurate in detecting the presence of residual thrombus.…”

The mechanisms of canalisation in deep vein thrombosis

“…Recent occlusive thrombi often show narrow zones of detachment from the intimal endothelium forming clefts or pockets between part of the thrombus and the vein. They have been noted in experimental venous thrombi (Kwaan and Astrup, 1965;Flanc, 1968;Scott, 1968),and are referred to by Fegan (1967) in therapeutically induced thrombi in superficial leg veins. The pockets form at the same time as other parts of the thrombus become attached to the vein ( fig.…”

Role of monocytes and macrophages in angiogenesis

“…Older studies have described in detail the structural modifications accompanying these processes in situ in fibrin-rich thrombi, including the clearance by cell-mediated proteolysis and phagocytosis of the interfibrillar spaces, with formation of "channel"-like tubes, further "colonized" by endothelial progenitors [110,112,[121][122][123]. The common themes are: (1) involvement of pluripotent mononuclear cells and (2) phagocytic and/or proteolytic activity of MC/Mph in modifying the thrombus to a pro-angiogenic state.…”