An Experimental Study of Histopathologic Effects of Hemostatic Agents Used in Spinal Surgery

Altun, İdiris

doi:10.1016/j.wneu.2016.02.052

Cited by 20 publications

(19 citation statements)

References 16 publications

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“…The discussion on this topic is still very limited in the world literature, and published scientific studies (mostly from Turkey) were conducted only on laboratory animals. Some of these works show a significant positive effect of oxidized cellulose on the prevention of epidural fibrosis (9, 10), another a significantly lower effect (11,12).…”

Section: Discussionmentioning

confidence: 99%

Topping Phenomenon with Recurrent Spinal Stenosis and Epidural Fibrosis Prevented with Oxidized Cellulose – a Case Report

Hart

2018

Acta Med. (Hradec Kralove, Czech Repub.)

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Lumbar spinal stenosis is a condition where the neural structures are compressed in the narrowed spinal canal and often situated only within a single specific segment of the spine, most frequently in the lumbar spine. A case report demonstrates a surgical solution of lumbar spinal stenosis with using oxidized cellulose as a prevention of post-operative adhesions and failed back syndrome. A female patient (68) with a significant pain of the lumbar spine lasting for a number of months due to advanced spondylosis, failing to respond to conservative treatment underwent instrumented, posterolateral fusion of affected segments. The patient re-arrived with pain due to spinal stenosis in another segments after 4 and then after 3 years. We repeatedly performed spinal fusion of the affected segments and applied an antiadhesive gel to the dural sac and the decompressed nerve roots to prevent the development of post-operative adhesions and the "failed back syndrome". Last surgical solution included mobilisation of the simultaneously constricted dural sac through laminectomy. This time we covered the sac using a haemostat made of oxidized cellulose (Traumacel FAM). After this treatment, the patient was again without significant difficulties.

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Section: Discussionmentioning

confidence: 99%

Topping Phenomenon with Recurrent Spinal Stenosis and Epidural Fibrosis Prevented with Oxidized Cellulose – a Case Report

Hart

2018

Acta Med. (Hradec Kralove, Czech Repub.)

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“…HA was hydrothermally synthesized in an autoclave using Ca(OH) 2 and Na 2 HPO 4 as reported by our group [9]. Generally, an amount of 0.37 g of Ca(OH) 2 was mixed with 300 mL of distilled water to make a suspension.…”

Section: Methodsmentioning

confidence: 99%

“…Generally, an amount of 0.37 g of Ca(OH) 2 was mixed with 300 mL of distilled water to make a suspension. Then 0.71 g Na 2 HPO 4 was added to react with Ca(OH) 2 . The prepared liquid mixture was magnetically stirred for 15 min.…”

Section: Methodsmentioning

confidence: 99%

“…However, these materials may have different problems for clinical practice. For example, as shown in a current spinal surgery study on rats, hemostatic polymers may cause undesirable complications such as inflammation and fibrosis [2]. On the other hand, the inorganic materials may be associated with non-biocompatible and/or nonbiodegradable nature, as well as hydration related thermal issue [3,4].…”

Section: Introductionmentioning

confidence: 95%

“…Recently, hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) has attracted interests from researchers because of its hemostatic properties, besides its more well-known bone healing function [5,6]. Initially HA was combined with hemostatic polymers to improve their limited osteoconductivity.…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Yin¹,

Zhou²,

Ni³

et al. 2017

Biol Eng Med

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Agent with both great blood clotting activity and bone regeneration ability is deserved to replace conventional bone wax. Recently, hydroxyapatite (HA) has attracted interests from researchers with its both hemostatic and bone healing functions. In present work, the blood clotting activity comparisons of HA to other potential bone repairing materials including calcium silicate, calcium combined attapulgite, calcium tripolyphosphate, and chitosan were carried out to show HA as a recommended hemostatic component to replace bone wax. In addition, the impacts of HA synthesis routes on its blood clotting activity were evaluated, indicating increase of surface area as well as active Ca 2+ of HA can greatly enhance blood clotting. With these attributes, it is expected HA can be a promising component in fabricating hemostatic materials in orthopedic applications as alternatives to bone wax.

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Evaluation of the effects of different hemostatic agent applications on mental nerve

Adak

Laçin

Şimşek

et al. 2022

Eur Arch Otorhinolaryngol

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An Experimental Study of Histopathologic Effects of Hemostatic Agents Used in Spinal Surgery

Cited by 20 publications

References 16 publications

Topping Phenomenon with Recurrent Spinal Stenosis and Epidural Fibrosis Prevented with Oxidized Cellulose – a Case Report

Topping Phenomenon with Recurrent Spinal Stenosis and Epidural Fibrosis Prevented with Oxidized Cellulose – a Case Report

Hydroxyapatite: a promising hemostatic component in orthopaedic applications

Evaluation of the effects of different hemostatic agent applications on mental nerve

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