An experimental study of fat necrosis

Panabokke, R. G.

doi:10.1002/path.1700750211

Cited by 23 publications

(3 citation statements)

References 15 publications

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“…The role of pancreatic lipase as the only media-tor in the development of fat necrosis has been questioned. Panabokke (13) was unable to produce fat necrosis with intra-abdominally administered pancreatic lipase (or trypsin). Lee et al (8) emphasized that the purity of lipase preparations were not ideal in the earlier experimental studies.…”

mentioning

confidence: 99%

Fat Necrosis in Human Acute Pancreatitis

Aho

Sternby

Nevalainen

1986

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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Fat necrosis in human acute pancreatitis. An immunohistological study. Acta path. microbiol. immunol. scand. Sect. A, 94: 101-105, 1986. Localization of phospholipase A2, lipase and colipase immunoreactivity were studied in parafin embedded tissue sections. The samples were taken from the pancreas of 12 patients suffering from acute haemorrhagic necrotizing pancreatitis, and from diseased adipose tissue of 7 patients suffering from traumatic mammary fat necrosis. Peroxidase-antiperoxidase immunohistology revealed consistent positive reaction against phospholipase A,, lipase and colipase at the border of fat necrosis in pancreatic interlobular adipose tissue and in peripancreatic, mesenterial and retroperitoneal fat. The fat necroses of the breast were devoid of reaction. The results support the idea that in addition to lipase colipase and phospholipase A2 participate in the development of fat necrosis in acute pancreatitis. Pancreatic lipolytic enzymes are not present in the adipose tissue in mammary fat necrosis.

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confidence: 99%

Fat Necrosis in Human Acute Pancreatitis

Aho

Sternby

Nevalainen

1986

Acta Pathologica Microbiologica Scandinavica Series A :Patholog

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“…This latter factor might be crucial in the development of fat necrosis. It has been suggested that the massive fat necrosis was the result of an injury to the cell membrane associated with ischemia (10,18). If that were true, then the adult animals which were infected at room temperature would not develop extensive brown adipose tissue damage because of the high level of NE.…”

Section: Discussionmentioning

confidence: 98%

Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure

Grodums¹,

Dempster²

1970

Can. J. Microbiol.

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GRODUMS, E. I., and G. DEMPSTER. 1970. Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure. Can. J. Microbial. 16: 833-839.On acute cold exposure the normal brown adipose cells in the mouse interscapular pad underwent morphological changes apparently as a result of loss and redistribution of the intracellular lipid globules; on continued cold exposure the globules increased in numbers and size. If adult female mice were inoculated with coxsackievirus B-3 during acute cold exposure and returned to normal room temperature soon afterwards, the viral damage in the brown adipose tissues was seriously aggravated; if on the other hand they were left in the cold for the duration of the infection, the damage was aggravated to a lesser degree. Finally, if cold-acclimated mice were inoculated the lesion was localized in one area of the pad.In contrast, the myocardial damage was aggravated only in those mice which were inoculated during acute cold exposure and left in the cold. The cox. B-3 pathogenesis in the brain showed no clear-cut variations resulting from changes in the ambient temperature. The infectious amount of virus recovered from the heart and brain appeared to be greater and persist longer, if the mice were subjected to a prolonged cold exposure.The cold exposure, however, failed completely to increase the age susceptibility of mice to cox. B-2.

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“…18 Fat necrosis has been reproduced in rats injected with pancreatic extract into the peritoneal omentum. 19 However, Berman et al found that neither incubation of human breast tissue with high concentrations of commercially available amylase and lipase nor incubation of normal human skin with serum from an affected patient produced fat necrosis. 20 More recently immunohistochemical methods have allowed for the detection of pancreatic-specific lipase in areas of subcutaneous fat necrosis in patients with pancreatic disease.…”

Section: Discussionmentioning

confidence: 99%

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

et al. 2000

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Background: Subcutaneous fat necrosis associated with pancreatic disease is a rare event. The clinical cutaneous findings are non‐specific erythematous nodules with central softening located predominantly on the lower extremities. The histopathologic features of these lesions are very characteristic and diagnostic. Methods: We present an unusual case of pancreatic panniculitis associated with lupus pancreatitis in a 21‐year‐old African American female. The patient presented with lower extremity skin nodules, arthralgia, and serositis prior to the diagnosis of systemic lupus and pancreatitis. The skin lesions progressed despite normalization of serum pancreatic enzymes. Following femoral vein catheterization for renal dialysis, she developed a large indurated area over the left lower quadrant, flank, groin, and upper thigh measuring 25 cm. She was treated with repeated debridement, tissue grafts, and hyperbaric oxygen because of a clinical suspicion of necrotizing fasciitis. Results: Examination of skin biopsies and debrided tissue revealed the pathognomonic features of pancreatic panniculitis without any evidence of necrotizing fasciitis. Organisms were not detected by tissue examination or microbiologic cultures. Conclusions: This case illustrates the potential role of vascular trauma in the pathogenesis of pancreatic panniculitis.

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An experimental study of fat necrosis

Cited by 23 publications

References 15 publications

Fat Necrosis in Human Acute Pancreatitis

Fat Necrosis in Human Acute Pancreatitis

Changes in brown adipose tissues and coxsackievirus B pathogenesis in mice on acute and chronic cold exposure

A fatal case of pancreatic panniculitis presenting in a young patient with systemic lupus

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