An experimental study for diagnosis of burn depth

Gürsu, K. Güler

doi:10.1016/0305-4179(77)90124-3

Cited by 25 publications

(3 citation statements)

References 26 publications

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“…It is based on the “rule of nines”, which was originally developed to assess the area of involvement in a burn case. [ 10 ] In this, each of the following 11 body parts is awarded 9% of BSA (head and neck, 2X arms, 2X anterior and posterior legs, 4X trunk) and the remaining 1% is for genitalia. The other way to calculate the area involved is by calculating the number of patient's hand areas affected, where one hand print reflects 1% BSA.…”

Section: Introductionmentioning

confidence: 99%

Disease Assessment in Psoriasis

Manchanda,

De,

Das

et al. 2023

Indian Journal of Dermatology

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Researchers are making all out efforts worldwide, to find a serological marker to monitor the disease severity and/or measure efficacy of the drug. There are many potential molecular targets being investigated as a candidate marker. However, till date there has been no significant breakthrough. Thus, various scoring systems have been devised to evaluate the disease severity in psoriasis. In spite of constant revisions of the scores being currently used, from time to time. None of the scores yet satisfy all the validation criteria desired of an ideal scoring system. And this is partly also because of the fact that the psoriasis has such a huge range of clinical variants. Nevertheless, in the recent past, significant progress has been made in this direction.

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Section: Introductionmentioning

confidence: 99%

Disease Assessment in Psoriasis

Manchanda,

De,

Das

et al. 2023

Indian Journal of Dermatology

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“…There are a variety of wound assessment tool guides available such as the Pressure Ulcer Scale for Healing [5], Leg Ulcer Measurement Tool [6], the TIME framework [7] and recently, the triangle of wound assessment [8]. These paradigms for tracking the condition of the wound rely on the skill and experience of the clinician [9], sometimes require costly and invasive biopsies [10] and can be time-consuming. There is a need for an easy-to-use, noninvasive and well-validated wound assessment methodology with high biochemical specificity.…”

Section: Introductionmentioning

confidence: 99%

Depth-sensitive Raman spectroscopy for skin wound evaluation in rodents

Wang

Tian

et al. 2019

Biomed. Opt. Express

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Raman spectroscopy has demonstrated great potential for skin wound assessment. Given that biochemical changes in wound healing is depth dependent as the skin is a layered structure, depth sensitive Raman spectroscopy could enhance the power of Raman spectroscopy in this application. Considering the critical importance of rodent studies in the field of skin wound assessment, it is necessary to develop and validate a system that can perform depth sensitive measurements in rat skin with a proper target depth range. In this manuscript, we report the design, optimization and evaluation of a new snapshot depth-sensitive Raman instrument for rat skin measurements. The optical design and optimization process are presented first. The depth sensitive measurement performance is characterized on both ex vivo porcine skin with a gradient of layer thickness and ex vivo rat skin samples with wounds. The statistical analysis of the measured Raman spectra demonstrates the feasibility of differentiation between the wound edge and healthy skin. Moreover, the accuracy of classification improves monotonically as more data from new depths are used, which implies that each depth offers additional information useful for classification. This instrument demonstrates the ability to perform snapshot depth sensitive Raman measurements from rat skin, which paves the way towards in vivo preclinical studies of rat skin wounds.

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“…In burns with an intermediate depth (also called partial thickness burns), the early prognostication of the likely burn wound outcome is difficult in the first days after injury [1,2]. In these intermediate burn depths, even experienced burn surgeons have an accuracy of their clinical assessment of burn depth of 60-80% [3][4][5][6][7]. In literature several potential objective methods to determine burn depth in an early stage after injury are reported, one of which is laser Doppler perfusion imaging (LDPI).…”

Section: Introductionmentioning

confidence: 99%