An Experimental Model for Tympanosclerosis: A Preliminary Report

Abstract

This study deals with an animal model where tympanosclerosis could be evoked with high reproducibility during the course of a sterile otitis media, induced by Eustachian tube obstruction. The histopathological features of this induced lesion were very similar to those reported in human specimens. It was concluded that this process is most probably triggered by a mechanical deformation of the tympanic membrane.

Achados otomicroscópicos e histológicos da miringoesclerose induzida em ratos: estudo crítico de um modelo experimental

“…Some studies may use otomicroscopic assessment or histology to study the incidence and dynamics of the formation of tympanosclerosis in animals in view of a possible etiological factor 12,14,[18][19][20] . Other studies tried to understand the etiopathogenic dynamics of tympanosclerosis, characterized by histological and ultrastructural affections.…”

“…13,16,17,21 Finally, there are studies directed only to presentation or discussion with an experimental model. 10,14 Many experimental studies use otomicroscopy as the assessment method for tympanosclerotic process 10,11,14,16,18,22 , but none of them tried to precisely correlate the affections found in the assessment and histology findings, meaning that there is no single study that shows reliability of images seen through otomicroscopy, that is, exam accuracy.…”

“…We used rats as experimental model because they have many practical advantages and similar anatomical and pathological conditions to human ME 14 , and also because it is the most commonly used animal for this purpose in the literature.…”

“…9 Experimental models have been used to induce tympanosclerosis from the beginning of the 1970 [10][11][12][13][14][15][16][17][18][19][20][21][22] , most of them performed in rats. These models used to be studied based on otoscopy, otomicroscopy and histology, with varied purposes, such as determination of etiological factors, study of etiopathogenesis, therapeutic drug action, etc.…”

Neuroglial Choristoma of the Middle Ear with Massive Tympanosclerosis: A Case Report and Literature Review

“…We recently experienced a case of neuroglialchoristoma of the middle ear and mastoid antrum with massive tympanosclerosis. To our knowledge, no cases on this combination have been previously reported and this combination mightsupport the inhalation theory of neuroglialchoristoma, given that poor aeration of the middle ear is a major cause of tympanosclerosis [3]. We report a case of neuroglialchoristoma of the middle ear with massive tympanosclerosis and a review of the relevant literature.…”