An Experimental Method for Measuring Aerosol Deposition Efficiency in the Human Oral Airway

Cheng, Kuo-Hsi; Cheng, Yung‐Sung; Yeh, Hsu‐Chi; Swift, David L.

doi:10.1202/0002-8894(1997)058<0207:aemfma>2.0.co;2

Cited by 7 publications

(10 citation statements)

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“…Several adult casts of the oral airway [2][3][4]17 or the nasal airway 7,18,19 have been described. However, to our knowledge, only two infant casts are available.…”

Section: Discussionmentioning

confidence: 99%

“…Several deposition models, both mathematical and anatomical, have been developed for adults. [1][2][3][4] These show that the upper airways of adults (nose, mouth pharynx down to the larynx) are an important trap for inhaled aerosols. 1,3,[5][6][7][8] However, adult models are not suitable to study deposition mechanisms in children for the following reasons.…”

Section: Introduction E Ffective Targeting Of Therapeutic Inhaledmentioning

confidence: 99%

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The Sophia Anatomical Infant Nose-Throat (Saint) Model: A Valuable Tool to Study Aerosol Deposition in Infants

Janssens

Jongste²,

Fokkens³

et al. 2001

Journal of Aerosol Medicine

115

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Relatively little is known about the variables that influence lung deposition of inhaled aerosols in children. A model of the upper airways of an infant could be a useful tool to study these variables in vitro. The objective of this study was to construct an anatomically correct model of the upper airways of a young child. A routine three-dimensional (3D) CT scan of the skull and neck of a child was selected that included the airway from the nasal cavity down to the subglottic region. The CT scan was edited to obtain an anatomically correct distinction between air and mucosa. Next, a model was constructed with a stereolithographic technique using a UV-sensitive resin. To validate the model, a 3D CT scan of the model was made and compared to the anatomy of the original image. To study aerosol deposition, the model was connected to a breathing simulator. Medical aerosols were delivered to the model by MDI/spacer during stimulated breathing. An upper airway model was made of a 9-month-old child that needed reconstructive surgery for a skull deformity and with normal anatomy of the upper airways. The nasal airway of the model was open for air passage and the oral airway was closed. The CT scan of the model matched the original in vivo CT scan closely. Aerosol deposition measurements showed that dose passing the model, or lung dose, was comparable with in vivo lung deposition data. We have constructed an anatomically correct model of the upper airways of a child, using a stereolithographic method for in vitro studies of aerosol deposition in young children. This model will be used to obtain insight in aerosol treatment that cannot be obtained in vivo.

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“…Several adult casts of the oral airway [2][3][4]17 or the nasal airway 7,18,19 have been described. However, to our knowledge, only two infant casts are available.…”

Section: Discussionmentioning

confidence: 99%

Section: Introduction E Ffective Targeting Of Therapeutic Inhaledmentioning

confidence: 99%

The Sophia Anatomical Infant Nose-Throat (Saint) Model: A Valuable Tool to Study Aerosol Deposition in Infants

Janssens

Jongste²,

Fokkens³

et al. 2001

Journal of Aerosol Medicine

115

View full text Add to dashboard Cite

show abstract

“…Nanoparticle deposition in an oral airway model As shown in Fig. 4, the simulated particle deposition efficiencies in an oral airway model (see Zhang et al, 2005) are compared with experimental data (Cheng et al, 1997) for particle diameters from 1 nm to 500 nm. The simulation results based on default Fluent programs and user-defined codes (including BM and NWI routines) are also included for comparison.…”

Section: Hygroscopic Growth Of Multi-component Dropletsmentioning

confidence: 99%

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

Zhang

Kleinstreuer

Hyun

2012

Journal of Aerosol Science

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“…[10][11][12][13][14]. Then, DFs for wide ranges of particle diameters 1 6 d p 6 150 nm and inhalation flow rates 7:5 6 Q in 6 60 l/min are presented (see Figs.…”

Section: Nano-particle Transport and Deposition Considering Cyclic Inmentioning

confidence: 99%

“…In a series of papers, Cheng et al [8][9][10][11][12] reported their measurements of mass transfer and deposition of ultrafine particles (3:6 < d p < 150 nm) in a human nasal and oral airway cast; Cohen et al [13] and Li et al [14] reported their experimental work on nano-particle and iodine vapor deposition in an upper tracheobronchial airway cast. For numerical simulations, the transport of nano-particles in an air stream can be considered as a ''two-phase flow'' problem, for which the basic modeling approaches have been recently analyzed by Kleinstreuer [15].…”

Section: Introductionmentioning

confidence: 98%

Airflow structures and nano-particle deposition in a human upper airway model

Zhang

Kleinstreuer

2004

Journal of Computational Physics

228

132

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An Experimental Method for Measuring Aerosol Deposition Efficiency in the Human Oral Airway

Cited by 7 publications

References 0 publications

The Sophia Anatomical Infant Nose-Throat (Saint) Model: A Valuable Tool to Study Aerosol Deposition in Infants

The Sophia Anatomical Infant Nose-Throat (Saint) Model: A Valuable Tool to Study Aerosol Deposition in Infants

Size-change and deposition of conventional and composite cigarette smoke particles during inhalation in a subject-specific airway model

Airflow structures and nano-particle deposition in a human upper airway model

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