An experimental Helicobacter suis infection causes gastritis and reduced daily weight gain in pigs

Bruyne, Ellen De; Flahou, Bram; Chiers, Koen; Meyns, Tom; Kumar, Smitha; Vermoote, Miet; Pasmans, Frank; Millet, Sam; Dewulf, Jeroen; Haesebrouck, Freddy; Ducatelle, Richard

doi:10.1016/j.vetmic.2012.06.031

Cited by 49 publications

(51 citation statements)

References 25 publications

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“…Phylogenetic analysis, especially of the partial ureA and ureB genes, strongly suggests that these ape-associated helicobacters constitute a new taxon/species belonging to the H. heilmannii sensu lato group (Haesebrouck et al, 2011) and also that these helicobacters colonizing chimpanzees and gorillas probably share a recent common ancestor with other gastric non-H. pylori Helicobacter species. Members of this group of gastric non-H. pylori Helicobacter species are known to cause gastric disease in their natural hosts, including pigs and non-human primates (Mackie and O'Rourke, 2003;Haesebrouck et al, 2009;De Bruyne et al, 2012). Future isolation attempts, for instance from the stomach mucosa of deceased chimpanzees/gorillas, may provide additional data regarding the identity and diversity of gastric Helicobacter taxa, although isolation of gastric non-H. pylori helicobacters in general is extremely difficult and timeconsuming .…”

Section: Discussionmentioning

confidence: 99%

Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas

Flahou

Modrý

Pomajbíková

et al. 2014

Veterinary Microbiology

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A B S T R A C TA number of Helicobacter species cause gastrointestinal or hepatic disease in humans, including H. pylori, gastric non-H. pylori helicobacters from animal origin and enterohepatic Helicobacter species. Little is known on the presence of Helicobacter species in great apes, our closest living relatives and potential reservoirs of microorganisms that might emerge in humans. The aim of the present study was to investigate the presence of gastric and enterohepatic Helicobacter species in African chimpanzees and gorillas. Fresh fecal samples were collected from wild endangered chimpanzees and critically endangered western lowland gorillas from different African National Parks, as well as wild-born captive animals from primate sanctuaries. Intact Helicobacter bacteria were demonstrated in feces by fluorescence in situ hybridization. Screening using a Helicobacter genus-specific PCR revealed the presence of Helicobacter DNA in the majority of animals in all groups. Cloning and sequencing of 16S rRNA gene fragments revealed a high homology to sequences from various zoonotic enterohepatic Helicobacter species, including H. cinaedi

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Section: Discussionmentioning

confidence: 99%

Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas

Flahou

Modrý

Pomajbíková

et al. 2014

Veterinary Microbiology

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“…Neither atrophy nor intestinal metaplasia is generally observed, but lymphoid aggregates and follicles are frequently seen in the gastric mucosa of infected pigs . A decrease in daily weight gain has also been demonstrated in experimentally infected pigs (De Bruyne et al 2012). It has been proposed that the bacteria may have an indirect effect on ulcer formation via induction of increased levels of acid secretion (Yeomans and Kolt 1996).…”

Section: Disease Association In Animalsmentioning

confidence: 95%

The Family Helicobacteraceae

et al. 2014

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“…In the Mongolian gerbil model, infection with H. suis led to the development of MALT lymphoma-like lesions in some animals [63] , and in experimentally infected pigs, H. suis induced severe gastritis and a significant reduction in weight gain [103] . Concerning H. bizzozeronii, experimental infections in BALB/c, C57BL/6, SJL, and CFW mice showed that bacteria were mainly located in the gastric pits, dispersed through the mucous layer of the surface epithelium, or in close association with the parietal cells [104] .…”

Section: Infectionsmentioning

confidence: 99%

Helicobacter heilmannii sensu lato: An overview of the infection in humans

Bento-Miranda

Figueiredo

2014

WJG

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Helicobacter heilmannii sensu lato (H. heilmannii s.l.) is a group of gastric non-Helicobacter pylori Helicobacter species that are morphologically indistinguishable from each other. H. heilmannii s.l. infect the stomach of several animals and may have zoonotic potential. Although the prevalence of these infections in humans is low, they are associated with gastric pathology, including mucosa-associated lymphoid tissue lymphoma, making them a significant health issue. Here, the taxonomy, epidemiology, microbiology, diagnosis, and treatment of these infections will be reviewed. The gastric pathology associated with H. heilmannii s.l. infections in humans will also be addressed. Finally, the features of the complete bacterial genomes available and studies on species-specific pathogenesis will be reviewed. The understanding of the mechanisms that underlie gastric disease development mediated by the different bacterial species that constitute H. heilmannii s.l. is essential for developing strategies for prevention and treatment of these infections. Core tip: Helicobacter heilmannii sensu lato is a group of non-Helicobacter pylori Helicobacter species that infect the stomach of animals and humans. In the human stomach, these infections are associated with several pathologies, but it is currently unknown whether certain species are more often associated with a certain disease outcome than others. The access to bacterial genomes together with the availability of increasing numbers of in vitro isolates will allow significant advances in the understanding of species-specific bacteria-host interactions in disease pathogenesis and will be essential for future development of strategies to prevent and treat these infections.

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An experimental Helicobacter suis infection causes gastritis and reduced daily weight gain in pigs

Cited by 49 publications

References 25 publications

Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas

Diversity of zoonotic enterohepatic Helicobacter species and detection of a putative novel gastric Helicobacter species in wild and wild-born captive chimpanzees and western lowland gorillas

The Family Helicobacteraceae

Helicobacter heilmannii sensu lato: An overview of the infection in humans

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