An experimental approach to identifying the genotoxic risk from cooked meat mutagens

Loprieno, N.; Boncristiani, Guido; Loprieno, G.

doi:10.1016/0278-6915(91)90077-k

Cited by 24 publications

(4 citation statements)

References 19 publications

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“…This could be a consequence of ingesting lower levels of some muta- gens such as benzo(a)pyrene and other food mutagens that are present in cooked meat. In addition, a diet rich in vegetables increases the levels of antioxidants and vitamins (potentially antimutagenic micronutrients), which could reduce genetic damage [Loprieno et al, 1991;Duthie et al, 1996]. It should be noted that Fenech found that differences in chromosomal damage between vegetarians and nonvegetarians were dependent on the age of the study group [Fenech and Rinaldi, 1995;Fenech, 1998b].…”

Section: Discussionmentioning

confidence: 95%

Occupational exposure to pesticides and cytogenetic damage: Results of a Hungarian population study using the micronucleus assay in lymphocytes and buccal cells

Pastor

Creus

Xamena

et al. 2002

Environ and Mol Mutagen

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The frequency of micronuclei (MN) in peripheral blood lymphocytes and in buccal epithelial cells was used as a biomarker of genotoxic effects resulting from occupational exposure to pesticides. In addition, the cytokinesis-block proliferation index (CBPI) was calculated to detect possible variations in the proliferative kinetics of lymphocytes due to pesticide exposure. This study was performed on 84 pesticide-exposed workers and 65 unexposed controls from Hungary. The pesticide-exposed workers, classified as moderately and highly exposed, were also evaluated separately. Statistical evaluation of the cytogenetic biomarkers indicated that there were no significant differences between pesticide-exposed workers and controls, nor between moderately and highly exposed workers. Nevertheless, the statistical analysis revealed that additional factors such as age, sex, ingestion of raw vegetables, and working as a pesticide applicator affected lymphocyte MN frequency. In addition, age, sex, and smoking affected the frequency of MN in buccal cells. Results from the CBPI analysis showed that the proliferation index decreased with pesticide exposure and that this parameter was also affected by smoking and by the gender of individuals. The results of this study indicate no significant increase in MN in this group of Hungarian workers; however, the reduced CBPI in the highly exposed population suggests a possible genotoxic effect of pesticide exposure.

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Section: Discussionmentioning

confidence: 95%

Occupational exposure to pesticides and cytogenetic damage: Results of a Hungarian population study using the micronucleus assay in lymphocytes and buccal cells

Pastor

Creus

Xamena

et al. 2002

Environ and Mol Mutagen

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“…It could be possible that a major factor in the mutagenic activity correlation is the level of A␣C and MeA␣C generated in the smoke. The co-mutagens harman and norharman may play a role in mutagenicity of smoke condensate by enhancing the mutagenicity of HAAs [10]. For example, it has been estab- Fig.…”

Section: Analysis Of Reference Cigarettesmentioning

confidence: 99%

“…Except for harman and norharman, which are not mutagenic, about 20 HAAs identified in food are potent mutagens [4]. Harman and norharman were found only to enhance the mutagenicity of the other HAAs [10].…”

Section: Introductionmentioning

confidence: 99%

Analysis of α- and β-carbolines in mainstream smoke of reference cigarettes by gas chromatography–mass spectrometry

Smith¹,

Qian²,

Zha³

et al. 2004

Journal of Chromatography A

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“…Subsequent identification of known compounds can be achieved by coupling LC to UV photodiode array-detector [54,65,66], in addition to confirmation by their retention time. Quantification of fluorescence HAs (nonpolar HAs and PhIP) can be achieved by simultaneous programmable fluorescence detection, which has been found to be 100-400 times more sensitive than UV detection [67,68]. These detectors are satisfactory for samples taken from simple chemical model systems or those subject to low to moderate heat treatments.…”

Section: 4mentioning

confidence: 99%

Heterocyclic amines: Chemistry and health

Cheng¹,

Chen²,

Wang³

2006

Molecular Nutrition Food Res

105

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Heterocyclic amines (HAs) occur at the ppb range in foods. Most of them demonstrate potent mutagenicity in bacteria mutagenicity test, and some of them have been classified by the International Agency for Research on Cancer as probable/possible human carcinogens. Their capability of formation even during ordinary cooking practices implies frequent exposure by the general public. Over the past 30 years, numerous studies have been stimulated aiming to alleviate human health risk associated with HAs. These studies contribute to the understanding of their formation, characterization, and quantification in foods; their mutagenesis/carcinogenesis, mechanisms of antimutagenesis by chemical or phytogenic modulators; and strategies to inhibit their formation. The chemistry of HAs, their implications in human health, factors influencing their formation, and feasible ways of suppression will be briefly reviewed. Their occurrence in trace amounts in foods necessitates continuous development and amelioration of analytical techniques. Various inhibitory strategies, ranging from modifying cooking conditions to incorporation of different modulators, have been developed. This will remain one of the foremost areas of research in the field of food chemistry and safety.

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An experimental approach to identifying the genotoxic risk from cooked meat mutagens

Cited by 24 publications

References 19 publications

Occupational exposure to pesticides and cytogenetic damage: Results of a Hungarian population study using the micronucleus assay in lymphocytes and buccal cells

Occupational exposure to pesticides and cytogenetic damage: Results of a Hungarian population study using the micronucleus assay in lymphocytes and buccal cells

Analysis of α- and β-carbolines in mainstream smoke of reference cigarettes by gas chromatography–mass spectrometry

Heterocyclic amines: Chemistry and health

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