An Experimental and Clinical Study of Quinidin Sulphate: I. Experimental

Korns, Horace Marshall

doi:10.1001/archinte.1923.00110130018003

Cited by 34 publications

(4 citation statements)

References 3 publications

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“…Finally, when the lethal dose was reached, the animal stopped breathing, although the heart continued to beat for three or four minutes longer. This is in accordance with the findings of Korns (14) who briefly mentioned that if artificial respiration was performed on guinea pigs they could withstand larger doses of quinidine. However, he failed to appreciate the importance of this observation, for he added that his dogs died of ventricular fibrillation, although respiration ceased only a few minutes before death.…”

Section: Non-lethal Expertimentssupporting

confidence: 92%

“…The duration of the Q-R-S complex was prolonged and the amplitude of the R and S waves was also increased. Frequently there was a slight delay in the P-R interval and even heart block as were noted by Korns (14), and Lewis et. al.…”

Section: Observations On the Heartmentioning

confidence: 56%

“…This; however, was accompanied by marked changes in the circulation. Vasquez and Leconte (13) and Korns (14) did not believe that quinidine ever really caused death. Exitus, they thought, was due to some underlying heart condition.…”

Section: Introductionmentioning

confidence: 99%

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The Mechanism of Death From Quinidine and a Method of Resuscitation; An Experimental Study

Gordon¹,

Matton²,

Levine³

1925

J. Clin. Invest.

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Section: Non-lethal Expertimentssupporting

confidence: 92%

Section: Observations On the Heartmentioning

confidence: 56%

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The Mechanism of Death From Quinidine and a Method of Resuscitation; An Experimental Study

Gordon¹,

Matton²,

Levine³

1925

J. Clin. Invest.

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“…Korns ( 6 ) reported ventricular fibrillation as the final outcome of quinidine infusion in his dogs. However, he used ether anesthesia without artificial respiration and noted a stoppage of respiration a few minutes before death.…”

mentioning

confidence: 98%

Effect of Quinidine, Procaine Amide and Mersalyl on Lethal Dose of Ouabain in Isolated Dog Heart.

Fawaz

1955

Experimental Biology and Medicine

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Digitalis is often used in combination with one or more of the following drugs: quinidine, procaine amide, mercurial diuretics. The endeffect of a sufficiently large dose of digitalis is ventricular fibrillation. preceded, as a rule: by ventricular ectopic rhythms. Quinidine is used for the treatment of ventricular ectopic rhythms, even those that are produced by digitalis. On the other hand, textbooks attribute to quinidine the property of producing ventricular premature beats. ventricular tachycardia and ventricular fibrillation, in other words, precisely those effects which it is supposed to suppress or prevent. Procaine amide is used, like quinidine, to suppress ventricular ectopic rhythms including those produced by digitalis( 1 ) , but nobody has described an arrhythmia-producing effect by procaine amide. The combined use of the drugs mentioned above, particularly digitalis and quinidine, has been the subject of much debate and investigation ( 2 ) . It thus appeared desirable to study the quantitative aspects of these drug combinations using isolated hearts.Methods and materials. Dog heart-lung preparations were performed by the conventional procedure using pentobarbital anesthesia. The blood donors were anesthetized with chloroform. The blood volume was about 900 cc and the resistance was maintained a t 6.8 cm Hg. The method of Farah ( 3 . 3 ) was used in measuring the lethal dose of ouabain. The rate of infusion was not far from the "optimal" rate. i.e., the rate below which there is no further decrease in the lethal dose. In all experiments with intact dogs pentobarbital anesthesia was used with artificial respiration. The following brands of drugs were used: Ouabain, E. Merck, Darmstadt ; Quinidine sulfate, Jlallinckrodt, V.S.P. : Procaine amide. (Pronestyl) Squibb; Jlersalyl. (Gortulin) n'inthrop. *This study has been supported by a grant from -. -__-__ the American Heart Association.Results. Oiiabain controls. -4s controls we have utilized Farah's (3,4) results most of which were obtained in this laboratory. In addition, we have performed a few more experiments which are essentially in agreement with those of Farah (Table I).Small amounts of quinidine sulfate (20 mg or less) , when added to the venous reservoir of the heart-lung Ouabain + quinidine.

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Auricular Fibrillation

Wolff¹,

White²

1929

Arch Intern Med (Chic)

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An Experimental and Clinical Study of Quinidin Sulphate: I. Experimental

Cited by 34 publications

References 3 publications

The Mechanism of Death From Quinidine and a Method of Resuscitation; An Experimental Study

The Mechanism of Death From Quinidine and a Method of Resuscitation; An Experimental Study

Effect of Quinidine, Procaine Amide and Mersalyl on Lethal Dose of Ouabain in Isolated Dog Heart.

Auricular Fibrillation

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