An Exercise Intervention for Breast Cancer Survivors With Bone Loss

Twiss, Janice J.; Waltman, Nancy; Berg, Kris; C, Ott; Gross, Gloria J.; Lindsey, Ada M.

doi:10.1111/j.1547-5069.2009.01247.x

Cited by 62 publications

(105 citation statements)

References 28 publications

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“…Improvements in muscle strength of the magnitude of 10% to 20% are considered meaningful and related to improved function and fewer falls [39]. Additional findings on muscle strength and balance, as well as more details on the ST exercises used in this RCT are described elsewhere [24]. The remaining results were organized to respond to study purposes:…”

Section: Muscle Strength and Balancementioning

confidence: 99%

“…Certified ETs demonstrated exercises to subjects and safety precautions in performing exercises, monitored performance in exercises, instructed subjects how to progressively increase weights lifted, and assisted subjects to transition from home-based to fitness center exercises. Exercise trainers made home or fitness center visits to subjects every 2 weeks at the beginning of homebased and fitness center exercises and every 2 months for the remainder of the 24 exercises generally involved temporary muscle soreness for up to 2 days following initiation of exercises or increase in weights lifted. If subjects complained of discomfort beyond the expected muscle soreness, exercises were not performed until the discomfort resolved.…”

Section: St Exercisesmentioning

confidence: 99%

“…They were excluded for conditions that prevented ST exercises, risedronate, calcium, or vitamin D intake. More specific eligibility criteria were reviewed elsewhere [24].…”

Section: Samplementioning

confidence: 99%

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The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial

et al. 2009

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This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were ≥50% adherent to exercise had no improvement in BMD but were less likely to lose BMD. Introduction This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33% radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. Methods Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. Results After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81%) and spine (+2.85%) and significant decreases in Alkphase B (−8.7%) and serum NTx (−16.7%). Women who also exercised had additional increases in BMD at the femoral neck (+0.29%), total hip (+0.34%), spine (+0.23%), total radius (+0.30%), and additional decreases in Alkphase B (−2.4%) and Serum NTx (−6.5%). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were ≥50% adherent to exercise were less likely to lose BMD at the total hip (chi-square [1]=4.66, p=0.03) and femoral neck (chi-square [1]=4.63, p=0.03).

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Section: Muscle Strength and Balancementioning

confidence: 99%

Section: St Exercisesmentioning

confidence: 99%

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The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial

et al. 2009

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“…Bone fractures due to osteoporosis are caused by both skeletal (bone loss) and nonskeletal problems (impaired balance and muscle loss) NIH 2000). Normal muscle mass causes a direct tension on bone and greater bone formation at remodeling process (Twiss et al 2009). Bone loss as well as muscle loss occurs by increasing age and almost at the same time.…”

mentioning

confidence: 99%

The effect of n-3 fatty acids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial

Salari

Asalforoush

Ameri

et al. 2009

AGE

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Recently, n-3 fatty acids are in the center of attention for their potent anti-inflammatory effects. Osteoporosis as a chronic senile disease is associated with inflammation, and the role of inflammatory mediators has been demonstrated in recent years. The beneficial effects of n-3 fatty acids on bone were proven in many animal studies, while to date, no conclusive data is available in human. The aim of this study was to evaluate the impact of n-3 fatty acids on bone biomarkers in osteoporotic postmenopausal women. Twenty-five osteoporotic postmenopausal women were recruited in the study and randomized in treatment and control groups. The patients received 900 mg n-3 fatty acid capsules or placebo per day for 6 months. Serum levels of osteocalcin, bone alkaline phosphatase (BALP), calcium, vitamin D, and parathormone and urine concentration of pyridinoline (Pyd) were measured at baseline, second month, and sixth month in both groups. In the treatment group, compared with baseline, at the second month, osteocalcin increased slightly; thereafter, it showed decrement trend until the end of the study. In the control group, it decreased all over the study. None of these changes was significant. BALP showed nonsignificant decrease from baseline over the time in both groups. Urine level of Pyd decreased significantly (P<0.05) in the treatment group, while no significant change was seen in the control group. Serum calcium and vitamin D increased in both groups; however, changes were not significant. No significant changes were seen in calcium clearance and parathormone. In conclusion, n-3 fatty acids can decrease bone resorption; however, it could not affect bone formation significantly after 6 months treatment. Further investigations are recommended.

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“…Exercising leads, above all, to improvement in the medio-lateral direction and individuals are then able to control movement at the hip joints within a greater range and with better results (Nagy et al, 2007). Twiss et al (2009) found improvements in balance after carrying out yearly exercises focused on the development of muscular strength and weight training. The number of falls in those exercising dropped, though insignificantly.…”

Section: The Effect Of Physical Activity On Balance and Risk Of Fallsmentioning

confidence: 99%

The Effect of Exercise on Bone Mineral Density, Bone Markers and Postural Stability in Subjects with Osteoporosis

Janura¹,

Krhutová²,

Svoboda³

et al. 2012

Osteoporosis

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An Exercise Intervention for Breast Cancer Survivors With Bone Loss

Abstract: More studies are needed for examining relationships between muscle strength and balance in postmenopausal BCS with bone loss and their incidence of falls and fractures.

Cited by 62 publications

References 28 publications

The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial

The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial

The effect of n-3 fatty acids on bone biomarkers in Iranian postmenopausal osteoporotic women: a randomized clinical trial

The Effect of Exercise on Bone Mineral Density, Bone Markers and Postural Stability in Subjects with Osteoporosis

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