An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

Tian, Yonglu; Yang, Chang; Cui, Yaxuan; Su, Feng; Wang, Yongjie; Wang, Yangzhen; Yuan, Pingzhi; Shang, Shujiang; Li, Hao; Zhao, Jizong; Zhu, Dong‐Ya; Tang, Shiming; Cao, Peng; Liu, Yunbo; Wang, Xun-li; Wang, Liecheng; Zeng, Wen‐Bo; Jiang, Hongmei; Zhao, Fei; Luo, Min‐Hua; Xiong, Wei; Qiu, Zilong; Li, Xiang-Yao; Zhang, Chen

doi:10.1016/j.celrep.2018.01.050

Cited by 24 publications

(29 citation statements)

References 42 publications

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“…In particular, the idea that LTP in the hippocampus supports associative memory formation has been widely accepted and has only rarely been questioned (Bannerman et al, 2014). As for short-term plasticity, it has been experimentally characterized in hippocampal neurons and considered to be one candidate mechanism for short-term memory (Erickson et al, 2010; Wang et al, 2017b; Tian et al, 2018). In the present study, both long-term and short-term plasticity of the CA3-CA1 pathway in CUS was ameliorated by LFPMF, in line with behavioral manifestations of MWM.…”

Section: Discussionmentioning

confidence: 99%

Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function

et al. 2019

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Transcranial magnetic stimulation (TMS) has shown great promise as a medical treatment of depression. The effectiveness of TMS treatment at high frequency has been well investigated; however, low-frequency TMS in depression treatment has rarely been investigated in depression-induced cognitive deficits. Herein, this study was carried out to assess the possible modulatory role of low-frequency pulsed magnetic field (LFPMF) on reversing cognitive impairment in a model of depression induced by chronic unpredictable stress (CUS). Wistar rats were randomly allocated into four groups as follows: a control group (CON), a control applied with LFPMF (CON + LFPMF), a CUS group, and a CUS treated with LFPMF (CUS + LFPMF) group. During 8 weeks of CUS, compared to those in the CON group, animals not only gained less weight but also exhibited anhedonia, anxiety, and cognitive decline in behavioral tests. After 2-week treatment of LFPMF, a 20 mT, 1 Hz magnetic stimulation, it reversed the impairment of spatial cognition as well as hippocampal synaptic function including long-term potentiation and related protein expression. Thus, LFPMF has shown effectively improvements on depressant behavior and cognitive dysfunction in CUS rats, possibly via regulating synaptic function.

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Section: Discussionmentioning

confidence: 99%

Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function

et al. 2019

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“…All imaging experiments were performed as previously reported (Jiang et al , 2017; Su et al , 2016; Tian et al , 2018; Wei et al , 2016). A detailed description of the methods is available at Bioinformatics online.…”

Section: Methodsmentioning

confidence: 99%

Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging

Wang

et al. 2019

Bioinformatics

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Motivation Functional imaging at single-neuron resolution offers a highly efficient tool for studying the functional connectomics in the brain. However, mainstream neuron-detection methods focus on either the morphologies or activities of neurons, which may lead to the extraction of incomplete information and which may heavily rely on the experience of the experimenters. Results We developed a convolutional neural networks and fluctuation method-based toolbox (ImageCN) to increase the processing power of calcium imaging data. To evaluate the performance of ImageCN, nine different imaging datasets were recorded from awake mouse brains. ImageCN demonstrated superior neuron-detection performance when compared with other algorithms. Furthermore, ImageCN does not require sophisticated training for users. Availability and implementation ImageCN is implemented in MATLAB. The source code and documentation are available at https://github.com/ZhangChenLab/ImageCN. Supplementary information Supplementary data are available at Bioinformatics online.

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“…Emotional and episodic memory is partially regulated by glutamatergic neurons in the mPFC [9,23,24,29]; thus, we asked whether fear learning and memory were affected after engrafting human glutamatergic neurons into this region. Notably, the percentage of freezing in the fear conditioning test was higher in the grafted group than in the control group (Fig.…”

Section: Engrafted Organoids Extended Long-distance Projections Into mentioning

confidence: 99%

“…The medial prefrontal cortex (mPFC) is a deep region of the cerebral cortex that controls numerous critical brain functions, such as higher cognitive functions, emotions, and goal-directed behaviors [8,9]. Abnormalities in the mPFC are associated with a variety of human disorders, such as cognitive deficits, drug addiction, autism, and depression [9][10][11][12]. Furthermore, the mPFC is involved in many neural circuits that include mPFC-lateral hypothalamus (LH) projections [13].…”

Section: Introductionmentioning

confidence: 99%

Human cerebral organoids establish subcortical projections in the mouse brain after transplantation

Dong

Chen

et al. 2020

Mol Psychiatry

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Numerous studies have used human pluripotent stem cell-derived cerebral organoids to elucidate the mystery of human brain development and model neurological diseases in vitro, but the potential for grafted organoid-based therapy in vivo remains unknown. Here, we optimized a culturing protocol capable of efficiently generating small human cerebral organoids. After transplantation into the mouse medial prefrontal cortex, the grafted human cerebral organoids survived and extended projections over 4.5 mm in length to basal brain regions within 1 month. The transplanted cerebral organoids generated human glutamatergic neurons that acquired electrophysiological maturity in the mouse brain. Importantly, the grafted human cerebral organoids functionally integrated into pre-existing neural circuits by forming bidirectional synaptic connections with the mouse host neurons. Furthermore, compared to control mice, the mice transplanted with cerebral organoids showed an increase in freezing time in response to auditory conditioned stimuli, suggesting the potentiation of the startle fear response. Our study showed that subcortical projections can be established by microtransplantation and may provide crucial insights into the therapeutic potential of human cerebral organoids for neurological diseases.

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An Excitatory Neural Assembly Encodes Short-Term Memory in the Prefrontal Cortex

Cited by 24 publications

References 42 publications

Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function

Low-Frequency Pulsed Magnetic Field Improves Depression-Like Behaviors and Cognitive Impairments in Depressive Rats Mainly via Modulating Synaptic Function

Efficient implementation of convolutional neural networks in the data processing of two-photon in vivo imaging

Human cerebral organoids establish subcortical projections in the mouse brain after transplantation

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