An excess of testicular germ cell tumors in down's syndrome

Satgé, Daniel; Sasco, Annie J.; Curé, Hervé; Leduc, Bernard; Sommelet, D.; Vekemans, Michel

doi:10.1002/(sici)1097-0142(19970901)80:5<929::aid-cncr14>3.3.co;2-e

Cited by 7 publications

(11 citation statements)

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“…The close relationship between testicular cancer and Down's syndrome has recently been discussed (2–6). The overall risk for leukemia and testicular cancer in Down's syndrome is significantly higher than in the general population (13–15).…”

Section: Discussionmentioning

confidence: 99%

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Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome

Amano

Shiotsu

Tamura

et al. 2007

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We here present a case of mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome. A 20-year-old Japanese man with a mass in the left inguinal region underwent orchidectomy as a left testicular tumor was suspected. Histology showed a mixed germ-cell tumor with embryonal carcinoma and yolk sac tumor with syncytiotrophoblastic giant cells occurring in a cryptorchid testis. Chromosomal analysis of peripheral lymphocytes disclosed a karyotype of 47,XY,+21[20]. Our case provides further evidence that these three conditions-Down's syndrome, cryptorchidism and testicular germ cell tumor-may be closely associated. To our knowledge this is the first case of mixed germ cell tumor arising in a patient with Down's syndrome and cryptorchidism.

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Section: Discussionmentioning

confidence: 99%

“…The relationship between Down's syndrome and cryptorchidism has been described previously (1). In addition, an association between Down's syndrome and testicular cancer has been demonstrated (2–6). Eight cases of testicular carcinoma with the cryptorchidism of Down's syndrome have been reported (4, 5, 7–12).…”

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confidence: 99%

Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome

Amano

Shiotsu

Tamura

et al. 2007

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“…Interestingly, the excess of germ cell tumours, particularly of the testis, is also observed in adults with DS. 4,8 Yours sincerely, Daniel SATGÉ*, Annie J. SASCO and Brigitte LACOUR…”

Section: Dear Sirmentioning

confidence: 99%

Are solid tumours different in children with Down's syndrome?

Satgé¹,

Sasco²,

Lacour³

2003

Intl Journal of Cancer

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“…9 A l so, there seems to be an i ncreased ri sk i n testi cul ar carci noma i n men w i th Dow n syndrome w hi ch i s a condi ti on that i s al so associ ated w i th i ncreased l evel s of serum FSH. 9 Secondl y, there i s remarkabl e si mi l ari ty i n geographi c di stri buti on of di zygoti c tw i nni ng and l arger testi cul ar vol ume and the i nci dence of testi s tumours. 10,11 In Scandi navi an popul ati ons both the i nci dence of DZ tw i nni ng and of testi cul ar cancer are among the hi ghest i n the w orl d. Contrasti ngl y, the i nci dence of both condi ti ons i s l ow est i n East A si an popul ati ons.…”

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confidence: 97%

Genetic risk factors in tumours of the testis: lessons from twin studies

Lambalk¹,

Boomsma

1998

Twin res.

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A thr eefol d i ncr ease for testi cul ar car ci noma has been r epor ted i n mal e di zygoti c tw i ns. I n thi s comment w e suggest the hypothesi s that over-exposur e to endogenousl y hyper secr eted Follicle Sti mul ati ng Hor mone (FSH) may underlie the pathogenesis. This is suppor ted by sever al fi ndi ngs. 1) FSH hypersecretion in mothers of dizygotic twins is most likely an autosomal trait implicating the possibility of male offspring with the same hormone characteristic. 2) In testicular carcinoma hi gher l evel s of cycl i n D2 ar e found. Thi s i s an FSH dependent sti mul ator y r egul ator of mi tosi s. 3) Ther e i s a mar k ed si mi l ar i ty betw een geogr aphi cal di str i buti on i n occur ence of di zygoti c tw i nni ng and testi cul ar car ci noma. 4) M en under goi ng sur ger y for testi cul ar car ci noma have hi gher FSH concentr ati ons and mal es w i th Dow n syndr ome have hi gher FSH l evel s and ar e mor e at r i sk to devel op testi cul ar car ci noma. We suggest to study FSH secr eti on i n mal es of familial dizygotic tw i ns and fur ther mor e the r i sk of devel opi ng testi cul ar car ci noma i n mal es w i th el evated FSH. These men w i th one testi cl e and/or w i th dysfuncti oni ng Ser tol i /Leydi g cel l s.

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An excess of testicular germ cell tumors in down's syndrome

Abstract: Surveillance of the gonads of male patients with DS is recommended. A better understanding of the factors involved could also help to identify risk factors in the general population.

Cited by 7 publications

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Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome

Mixed testicular germ cell tumor in an adult with cryptorchidism and Down's syndrome

Are solid tumours different in children with Down's syndrome?

Genetic risk factors in tumours of the testis: lessons from twin studies

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